Weichun Pan
University of Houston
33 Papers
38 Citations
Weichun Pan is an academic researcher from University of Houston. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 11, co-authored 14 publications. Previous affiliations of Weichun Pan include Technische Universität München.
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Papers
A Metastable Prerequisite for the Growth of Lumazine Synthase Crystals
Olga Gliko,Nikolaus Neumaier,Weichun Pan,Ilka Haase,Markus Fischer,Adelbert Bacher,Sevil Weinkauf,Peter G. Vekilov +7 more
TL;DR: Two novel features of phase transformations in solutions are illustrated: the existence of doubly metastable, short-lifetime dense phases and their crucial role for the growth of an ordered solid phase.
152
Nucleation of ordered solid phases of proteins via a disordered high-density state: Phenomenological approach
TL;DR: A simple phenomenological theory is presented that takes into account intermediate high-density metastable states in the nucleation process and shows that the growth rate of the near-critical and supercritical ordered clusters within the dense intermediate is a major factor for the overall nucleation rate.
140
Two-Step Mechanism of Homogeneous Nucleation of Sickle Cell Hemoglobin Polymers
TL;DR: It is shown that the homogeneous nucleation of HbS polymers follows a two-step mechanism with metastable dense liquid clusters serving as precursor to the ordered nuclei of the Hb S polymer.
121
Metastable Mesoscopic Clusters in Solutions of Sickle-Cell Hemoglobin
TL;DR: It is shown that solutions of all three Hb variants contain clusters of dense liquid, several hundred nanometers in size, which are metastable with respect to the Hb solutions, and if the clusters are a part of the nucleation mechanism of HbS polymers, the rate of HBS polymerization can be controlled by varying the cluster properties.
117
Origin of anomalous mesoscopic phases in protein solutions.
TL;DR: It is predicted and experimentally confirmed that cluster dynamics obey a universal, diffusion-like scaling with time and wave vector, including in the critical-like regime, and suggested ways to control protein aggregation are suggested.
109