[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online ( http://bioinf.spbau.ru/spades ). It is distributed as open source software.

SPAdes, a new genome assembly algorithm and its applications to single-cell sequencing ( 7th Annual SFAF Meeting, 2012)

Rapid improvements in sequencing and array-based platforms are resulting in a flood of diverse genome-wide data, including data from exome and whole-genome sequencing, epigenetic surveys, expression profiling of coding and noncoding RNAs, single nucleotide polymorphism (SNP) and copy number profiling, and functional assays. Analysis of these large, diverse data sets holds the promise of a more comprehensive understanding of the genome and its relation to human disease. Experienced and knowledgeable human review is an essential component of this process, complementing computational approaches. This calls for efficient and intuitive visualization tools able to scale to very large data sets and to flexibly integrate multiple data types, including clinical data. However, the sheer volume and scope of data pose a significant challenge to the development of such tools.

Integrative Genomics Viewer

CA : A Cancer Journal for Clinicians

Synergetic strengthening by designing of gradient nanostructures is a novel method to enhance strength in metals and alloys. Herein, we realize synergetic strengthening in strain-softening Zn alloy with gradient nanostructures. The results show that synergetic strengthening accounts for at least 25.5 pct of the yield strength of the strain-softening Zn alloy. The synergetic strengthening is induced by the microstructural gradient and the resultant strength gradient regardless of specific hardening or softening of the refined microstructures.

Gradient Microstructure Induced Synergetic Strengthening in Strain-Softening Zn Alloy

Traditional comparative learning sentence embedding directly uses the encoder to extract sentence features, and then passes in the comparative loss function for learning. However, this method pays too much attention to the sentence body and ignores the influence of some words in the sentence on the sentence semantics. To this end, we propose CMLM-CSE, an unsupervised contrastive learning framework based on conditional MLM. On the basis of traditional contrastive learning, an additional auxiliary network is added to integrate sentence embedding to perform MLM tasks, forcing sentence embedding to learn more masked word information. Finally, when Bertbase was used as the pretraining language model, we exceeded SimCSE by 0.55 percentage points on average in textual similarity tasks, and when Robertabase was used as the pretraining language model, we exceeded SimCSE by 0.3 percentage points on average in textual similarity tasks.

CMLM-CSE: Based on Conditional MLM Contrastive Learning for Sentence Embeddings

Peculiar Microstructure with High Damping Capacity for Alcrfe2ni X Medium Entropy Alloys

C Effect on the Amorphous Formation and Soft Magnetic Properties of Fe84.3si4b8p3-Xcxcu0.7 Alloys

In recent years, knowledge graphs have been widely applied as a uniform way to organize data and have enhanced many tasks requiring knowledge. In online shopping platform Taobao, we built a billion-scale e-commerce product knowledge graph. It organizes data uniformly and provides item knowledge services for various tasks such as item recommendation. Usually, such knowledge services are provided through triple data, while this implementation includes (1) tedious data selection works on product knowledge graph and (2) task model designing works to infuse those triples knowledge. More importantly, product knowledge graph is far from complete, resulting error propagation to knowledge enhanced tasks. To avoid these problems, we propose a Pre-trained Knowledge Graph Model (PKGM) for the billion-scale product knowledge graph. On the one hand, it could provide item knowledge services in a uniform way with service vectors for embedding-based and item-knowledge-related task models without accessing triple data. On the other hand, it's service is provided based on implicitly completed product knowledge graph, overcoming the common the incomplete issue. We also propose two general ways to integrate the service vectors from PKGM into downstream task models. We test PKGM in five knowledge-related tasks, item classification, item resolution, item recommendation, scene detection and sequential recommendation. Experimental results show that PKGM introduces significant performance gains on these tasks, illustrating the useful of service vectors from PKGM.

PKGM: A Pre-trained Knowledge Graph Model for E-commerce Application

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