Wei Yi
Novartis
8 Papers
10 Citations
Wei Yi is an academic researcher from Novartis. The author has contributed to research in topics: Histone & Histone H3. The author has an hindex of 7, co-authored 7 publications.
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Papers
Absolute Quantification of Histone PTM Marks by MRM-Based LC-MS/MS
Jun Gao,Rijing Liao,Yanyan Yu,Huili Zhai,Yingqi Wang,Ragna Sack,Antoine H.F.M. Peters,Antoine H.F.M. Peters,Jiajia Chen,Haiping Wu,Zheng Huang,Min Hu,Wei Qi,Chris Lu,Peter Atadja,Counde Oyang,En Li,Wei Yi,Shaolian Zhou +18 more
TL;DR: This method has been used to study translocated NSD2 (a histone lysine methyltransferase that catalyzes the histoneLysine 36 methylation) function with its overexpression in KMS11 multiple myeloma cells and successfully quantitated both individual and combinatorial histone marks.
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Specific and Efficient N-Propionylation of Histones with Propionic Acid N-Hydroxysuccinimide Ester for Histone Marks Characterization by LC-MS
Rijing Liao,Haiping Wu,Haibing Deng,Yanyan Yu,Min Hu,Huili Zhai,Pengyuan Yang,Shaolian Zhou,Wei Yi +8 more
TL;DR: A novel derivatization method that utilizes N-hydroxysuccinimide ester to specifically and efficiently derivatize both free and monomethylated amine groups in histones is reported, which can achieve excellent specificity and efficiency and prevent the side reactions.
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Epigenetically repressing human cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases.
TL;DR: Two HDMs, KDM4 and KDM6, which reverse the repressive histone H3-lysine 9 and lysine 27 methylation are focused on, suggesting pharmacological inhibition of these HDMs may potentially block hCMV lytic infection and reactivation, and control the viral infection associated diseases.
Quantitative Profiling of Combinational K27/K36 Modifications on Histone H3 Variants in Mouse Organs.
Yanyan Yu,Jiajia Chen,Yuan Gao,Jun Gao,Rijing Liao,Yi Wang,Counde Oyang,En Li,Chenhui Zeng,Shaolian Zhou,Pengyuan Yang,Hong Jin,Wei Yi +12 more
TL;DR: The data shed the new insights into histone codes functions in epigenetic regulation during cell differentiation and developmental process by investigating the pattern of the combinatorial K27/K36 marks for all three major histone H3 variants across five mouse organs.
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Sensitive and Precise Characterization of Combinatorial Histone Modifications by Selective Derivatization Coupled with RPLC-EThcD-MS/MS
Rijing Liao,Dan Zheng,Aiying Nie,Shaolian Zhou,Haibing Deng,Yuan Gao,Pengyuan Yang,Yanyan Yu,Lin Tan,Wei Qi,Jiaxi Wu,En Li,Wei Yi +12 more
TL;DR: A novel strategy that combines the selective histone peptide derivatization using N-hydroxysuccinimide propionate ester with reversed-phase liquid chromatography (RPLC) for the robust, sensitive, and reliable characterization of combinatorial histone PTMs is provided.
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