Wei Yang
China Pharmaceutical University
6 Papers
4 Citations
Wei Yang is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Chemistry & Cmax. The author has an hindex of 4, co-authored 6 publications.
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Papers
Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats.
TL;DR: A rapid, sensitive, and specific LC-MS/MS method has been developed for the determination of wogonin in different rat biological samples, and indicated a very high protein binding degree (over 90%), reducing substantially the free fraction of the compound.
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Comparative pharmacokinetic studies of racemic oxiracetam and its pure enantiomers after oral administration in rats by a stereoselective HPLC method.
Qiuyang Zhang,Wei Yang,Yue Yang,Han Xing,Qing Zhang,Junxiu Li,Yang Lu,Jiake He,Shuoye Yang,Di Zhao,Xijing Chen +10 more
TL;DR: The higher absorption and slower elimination suggest that enantiopure (S)-ORC could be a promising drug that efficiently reduces clinical dosage, improves therapeutic indices, decreases toxicology risks, and results in increased therapeutic ration.
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Epigallocatechin-3-gallate decreases the transport and metabolism of simvastatin in rats.
Wei Yang,Qiuyang Zhang,Yue Yang,Jiaqiu Xu,Ali Fan,Chung S. Yang,Ning Li,Yang Lu,Jiayin Chen,Di Zhao,Jiye Aa,Xijing Chen +11 more
TL;DR: The presently reported novel food–drug interaction between E GCG and simvastatin involves the inhibition of not only CYP450 enzymes but also OATPs by EGCG.
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Enantioselective HPLC determination of oxiracetam enantiomers and application to a pharmacokinetic study in beagle dogs.
Qiuyang Zhang,Wei Yang,Qing Zhang,Yue Yang,Junxiu Li,Yang Lu,Yi Zheng,Jiake He,Di Zhao,Xijing Chen +9 more
TL;DR: An enantioselective high-performance liquid chromatography method was developed and validated for the determination of oxiracetam enantiomers, a cognition and memory enhancer, in beagle dog plasma and was successfully applied to a pharmacokinetic study of individual enantiomer and racemic oxir acetam in beagles dogs after oral administration.
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Investigation on pharmacokinetics, tissue distribution and excretion of 1-triacontanol in rats by gas chromatography-tandem mass spectrometry (GC-MS/MS)
Chunfeng Wang,Ali Fan,Shuhua Deng,Wenchao Gao,Wei Zhang,Wei Yang,Xiaojie Zhu,Yang Lu,Xijing Chen +8 more
TL;DR: A sensitive gas chromatography-tandem mass spectrometry method was developed to explore the pharmacokinetic profiles, distribution and excretion of TA in Sprague-Dawley rats after oral administration of TA to show promising anti-tumor activity.
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