Wei Yang
Laboratory of Molecular Biology
15 Papers
103 Citations
Wei Yang is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: DNA & MutS-1. The author has an hindex of 13, co-authored 15 publications. Previous affiliations of Wei Yang include National Institutes of Health.
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Papers
Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.
TL;DR: An integrase tetramer formed by crystal lattice contacts bears structural resemblance to a related bacterial transposase, Tn5, and exhibits positively charged channels suitable for DNA binding.
Evidence for sequential action of two ATPase active sites in yeast Msh2-Msh6.
TL;DR: Differences in the two putative ATPase active sites are investigated by examining the properties of heterodimers containing alanine substituted for an invariant glutamic acid in the active site of either Msh2, Msh6 or both, which suggests sequential action of the two ATP enzyme active sites.
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Crystal structure of a SeqA-N filament: implications for DNA replication and chromosome organization.
Alba Guarné,Alba Guarné,Therese Brendler,Qinghai Zhao,Rodolfo Ghirlando,Stuart Austin,Wei Yang +6 more
TL;DR: A model of a SeqA filament interacting with multiple GATC sites that accounts for both origin sequestration and chromosome organization is proposed.
Crystal Structure and Biochemical Analysis of the MutS·ADP·Beryllium Fluoride Complex Suggests a Conserved Mechanism for ATP Interactions in Mismatch Repair
TL;DR: Crystallographic analysis of the Taq MutS·DNA·ABF complex indicated that although this complex was very similar to that of MutS ·DNA·ADP, both ADP·Mg2+ moieties in theMutS· DNA· ADP structure were replaced by ABF, and it is hypothesized that the presence of ABF is communicated between the two MutS subunits through the contact between the ordered loop and Domain III.
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Correlation of phenotype/genotype in a cohort of 23 xeroderma pigmentosum-variant patients reveals 12 new disease-causing POLH mutations.
K. Opletalova,Agnes Bourillon,Wei Yang,Caroline Pouvelle,Jacques Armier,Emmanuelle Despras,Ludovic Martin,Christine Mateus,Caroline Robert,Patricia Kannouche,Nadem Soufir,Alain Sarasin +11 more
TL;DR: Clinical and genetic features of the largest collection ever published of 23 XP‐V patients (ages between 21 and 86) from 20 unrelated families are described, reinforcing the necessity to protect XP‐Vs from sun exposure.
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