4 Papers
148 Citations
Wei Yan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Phospholipase & Arachidonic acid. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Dramatic Accumulation of Triglycerides and Precipitation of Cardiac Hemodynamic Dysfunction during Brief Caloric Restriction in Transgenic Myocardium Expressing Human Calcium-independent Phospholipase A2γ
David J. Mancuso,Xianlin Han,Christopher M. Jenkins,John J. Lehman,Nandakumar Sambandam,Harold F. Sims,Jingyue Yang,Wei Yan,Kui Yang,Karen G. Green,Dana R. Abendschein,Jeffrey E. Saffitz,Richard W. Gross +12 more
TL;DR: The participation of iPLA2γ in the remarkable lipid plasticity of myocardium, its role in generating signaling metabolites, and its prominent effects in modulating energy storage and utilization in myocardia in different metabolic contexts are identified.
59
Highly Selective Hydrolysis of Fatty Acyl-CoAs by Calcium-independent Phospholipase A2β: ENZYME AUTOACYLATION AND ACYL-CoA-MEDIATED REVERSAL OF CALMODULIN INHIBITION OF PHOSPHOLIPASE A2 ACTIVITY *
TL;DR: The results collectively identify the molecular species-specific acyl-CoA thioesterase activity of iPLA2 β, demonstrate the presence of a second active site that mediates iPLA 2 β autoacylation, and identify long-chain acyl -CoAs as potential candidates mediating calcium influx factor activity.
51
Dramatic Accumulation of Triglycerides and Precipitation of Cardiac Hemodynamic Dysfunction during Brief Caloric Restriction in Transgenic Myocardium Expressing Human
David J. Mancuso,Xianlin Han,Christopher M. Jenkins,John J. Lehman,Nandakumar Sambandam,Harold F. Sims,Jingyue Yang,Wei Yan,Kui Yang,Karen G. Green,Dana R. Abendschein,Jeffrey E. Saffitz,Richard W. Gross +12 more
- 01 Jan 2007
TL;DR: In this paper, the role of iPLA2γ in integrating lipid and energy metabolism was investigated in transgenic mice containing the α-myosin heavy chain promoter (αMHC) placed proximally to the human iPLA 2γ coding sequence that resulted in cardiac myocyte-restricted expression of the enzyme.
47
The Highly Selective Production of 2-Arachidonoyl Lysophosphatidylcholine Catalyzed by Purified Calcium-independent Phospholipase A2γ IDENTIFICATION OF A NOVEL ENZYMATIC MEDIATOR FOR THE GENERATION OF A KEY BRANCH POINT INTERMEDIATE IN EICOSANOID SIGNALING
Wei Yan,Christopher M. Jenkins,Xianlin Han,David J. Mancuso,Harold F. Sims,Kui Yang,Richard W. Gross +6 more
TL;DR: The heterologous expression of the human peroxisomal 63-kDa calcium-independent phospholipase A2γ (iPLA2γ) isoform in Sf9 cells is reported, and the identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine is identified.