13 Papers
58 Citations
Wei Yan is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Carcinogenesis & Gene. The author has an hindex of 8, co-authored 13 publications.
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Papers
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer
Peipei Xue,Fanfan Zeng,Qiuhong Duan,Juanjuan Xiao,Lin Liu,Ping Yuan,Linni Fan,Huimin Sun,Olesya S. Malyarenko,Olesya S. Malyarenko,Hui Lu,Ruijuan Xiu,Shaoqing Liu,Chen Shao,Jianmin Zhang,Wei Yan,Zhe Wang,Jianyong Zheng,Feng Zhu +18 more
TL;DR: It is investigated that abnormal branched-chain amino acids catabolism in colorectal cancer is a result of the disease process, with no role in disease initiation, and the process above could be inhibited by a BCKDK inhibitor, phenyl butyrate.
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Knockdown of survivin gene expression by RNAi induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721
TL;DR: RNAi can exert a knockdown of survivin gene expression in SMMC-7721 cells, and induce apoptosis and inhibit the growth of carcinoma cells.
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Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.
TL;DR: The data showed that Apr-1 plays a crucial role in cell proliferation by controlling cell cycle progression, implying a tumor-suppressor function of Apr- 1 in cholangiocarcinoma carcinogenesis.
Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21.
Qinlong Li,Wei Yan,Sheng-Quan Cheng,Shuang-ping Guo,Wenyong Wang,Zhipei Zhang,Li Wang,Jing Zhang,Wen-liang Wang +8 more
TL;DR: Results of cell cycle gene chips analysis showed up-regulation of p21 expression and down- regulation of TIMP3 in HHCC cells expressing ectogenic APMCF1, indicating that APMCf1 participates at least partially in cell cycle regulation through regulating genes such as p21 and TIMP 3.
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Isolation of a novel member of small G protein superfamily and its expression in colon cancer.
TL;DR: APMCF1 may be the gene coding human signal recognition particle receptor beta and belongs to the small-G protein superfamily and suggests it may play a role in colon cancer development.
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