Recent advances on protein separation and purification methods.

Molecular recognition displayed by naturally occurring receptors has continued to inspire new innovations aimed at developing systems that can mimic this natural phenomenon. Since 1930s, a technology called molecular imprinting for producing biomimetic receptors has been in place. In this technology, tailor made binding sites that selectively bind a given target analyte (also called template) are incorporated in a polymer matrix by polymerizing functional monomers and cross-linking monomers around a target analyte followed by removal of the analyte to leave behind cavities specific to the analyte. The success of the imprinting process is defined by two main figures of merit, that is, the imprinting factor, and selectivity, which are determined by comparing the amount of target analyte or structural analogue bound by the molecularly imprinted polymer (MIP) and the nonimprinted polymer (NIP). NIP is a control synthesized alongside the MIP but in the absence of the template. However, questions arise on whether these figures of merit are reliable measures of the imprinting effect because of the significant differences between the MIP and the NIP in terms of their physical and chemical characteristics. Therefore, this review critically looks into this subject, with a view of defining the best approaches for determining the imprinting effect.

Molecularly imprinted polymers-A closer look at the control polymer used in determining the imprinting effect: A mini review

Elemental migration and transformation during hydrothermal liquefaction of biomass.

Hydrothermal liquefaction of typical livestock manures in China: Biocrude oil production and migration of heavy metals

A molecularly imprinted polymer (MIP) film using catechol as the template was designed for adsorption of a range of phenols from water. Four different isotherm models (Langmuir (LI), Freundlich (FI), Langmuir-Freundlich (L-FI), and Brunauer, Emmett, and Teller (BET)) were used to study the MIP adsorption of five phenolic compounds: phenol (Ph), 2-methylphenol (2-MP), 3-methylphenol (3-MP), 2-chlorophenol (2-CP), and 4-teroctylphenol (4-OP). Each model was evaluated for its fit with the experimental data, and key parameters, including a number of binding sites and binding site energies, were compared. Though the LI, L-FI, and BET models showed good agreement for estimation of the number of binding sites and affinity for most adsorbates, no single model was suitable for all. The LI and L-FI models gave the best fitting statistics for the Ph, 2-MP, 3-MP, and 2-CP. The recognition of 4-OP, which has much higher binding affinities than the smaller phenolic compounds not attributable to hydrophobicity alone, was explained only by the BET model, which indicates the formation of multilayers. The BET model failed only with phenol. MIPs also showed higher adsorption capacities and improved homogeneity over the analogous non-imprinted polymers.

Comparison of Four Adsorption Isotherm Models for Characterizing Molecular Recognition of Individual Phenolic Compounds in Porous Tailor-Made Molecularly Imprinted Polymer Films

Molecularly imprinted polymers (MIPs) were designed and prepared via bulk thermal polymerization with gossypol as the template molecule and dimethylaminoethyl methacrylate as the functional monomer. The morphology and microstructures of MIPs were characterized by scanning electron microscope and Brunauer-Emmett-Teller surface areas. Static adsorption tests were performed to evaluate adsorption behavior of gossypol by the MIPs. It was found that adsorption kinetics and adsorption isotherms data of MIPs for gossypol were fit well with the pseudo-second-order model and Freundlich model, respectively. Scatchard analysis showed that heterogeneous binding sites were formed in the MIPs, including lower-affinity binding sites with the maximum adsorption of 252 mg/g and higher-affinity binding sites with the maximum adsorption of 632 mg/g. Binding studies also revealed that MIPs had favorable selectivity towards gossypol compared with non-imprinted polymers. Furthermore, adsorption capacity of MIPs maintained above 90% after 5 regeneration cycles, indicating MIPs were recyclable and could be used multiple times. These results demonstrated that prepared MIPs could be a promising functional material for selective adsorption of gossypol.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmr.2627

Preparation and evaluation of molecularly imprinted polymer for selective recognition and adsorption of gossypol.

Roxarsone, one of feed add drugs containing arsenic, has been most widely used in poultry and swine industry. Roxarsone discharged into the environment has caused serious pollution problem. Herein, a reusable functional material for selective recognition and adsorption of roxarsone and its derivatives were designed and synthesized. The interaction mechanism is based on acid-base interaction and surface molecular imprinting. Dual functionalized core-shell structure with silica gel as the core was prepared to use as carrier for surface molecularly imprinted polymers. Surface molecularly imprinted polymers for roxarsone was successfully designed and synthesized using 3-aminopropyltriethoxysilane and methyl acryloyloxypropyltriethoxy silane as functional monomers, Ethylene glycol dimethacrylate as crosslinker, Azobisisobutyronitrile as initiator, acetonitrile as solvent. Binding study showed that the recognition selectivity for roxarsone and its derivatives can be significantly improved (3.5-4 folds) with molecular imprinting. Moreover, the prepared functional material for selective recognition and adsorption of Roxarsone was reusable for multiple times without significant decreasing their adsorption capacities.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmr.2625

Functional organic material for roxarsone and its derivatives recognition via molecular imprinting.

MIL-101(Cr) based d-SPE/UPLC-MS/MS for determination of neonicotinoid insecticides in beverages

Preparation and application of recyclable multifunctional self-healing thioctic acid-based materials

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Papers

Preparation and evaluation of molecularly imprinted polymer for selective recognition and adsorption of gossypol.

Functional organic material for roxarsone and its derivatives recognition via molecular imprinting.

MIL-101(Cr) based d-SPE/UPLC-MS/MS for determination of neonicotinoid insecticides in beverages

Preparation and application of recyclable multifunctional self-healing thioctic acid-based materials