11 Papers
159 Citations
Wei Wen is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Protein kinase A & Protein subunit. The author has an hindex of 9, co-authored 10 publications.
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Papers
Identification of a signal for rapid export of proteins from the nucleus
TL;DR: The heat-stable inhibitor of cAPK contains a nuclear export signal that triggers rapid, active net extrusion of the C-PKl complex from the nucleus, and this NES (residues 35-49), fused or conjugated to heterologous proteins, was sufficient for rapid nuclear export.
1.2K
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion.
TL;DR: Results indicate that diffusion is sufficient to explain most aspects of C subunit subcellular localization.
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus.
D. A. Fantozzi,Alec Tate Harootunian,Wei Wen,Susan S. Taylor,James R. Feramisco,Roger Y. Tsien,J L Meinkoth +6 more
TL;DR: The catalytic subunit of cAMP-dependent protein kinase is inhibited by the regulatory (R) subunit and by a thermostable inhibitor (PKI), both inhibitors also affect the intracellular distribution of the C subunit as discussed by the authors.
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Human Regulatory Subunit RIβ of cAMP-Dependent Protein Kinases: Expression, Holoenzyme Formation and Microinjection into Living Cells
Rigmor Solberg,Kjetil Taskén,Wei Wen,Vincent M. Coghlan,J L Meinkoth,John D. Scott,Tore Jahnsen,Susan S. Taylor +7 more
TL;DR: The human regulatory subunit RIβ of cAMP-dependent protein kinases was expressed in Escherichia coli as a fusion protein with glutathione S -transferase.
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The Expression and Intracellular Distribution of the Heat-stable Protein Kinase Inhibitor Is Cell Cycle Regulated
TL;DR: The idea that PKIα plays an important role in the inhibition of nuclear C subunit activity required for cell cycle progression is supported, although a determination of the relative amounts of endogenous nuclear PKI and C-subunit will be required to substantiate this hypothesis.
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