Wei-Wei Luo
Chinese Academy of Sciences
19 Papers
Wei-Wei Luo is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 10, co-authored 16 publications. Previous affiliations of Wei-Wei Luo include Wuhan University.
Chat about Author
Papers
iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING
TL;DR: It is suggested that iRhom2 is essential for STING activity, as it regulates TRAPβ-mediated translocation and EIF3S5-mediated deubiquitination of STING.
231
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Huan Lian,Ru Zang,Jin Wei,Wen Ye,Ming-Ming Hu,Yun-Da Chen,Xia-Nan Zhang,Yi Guo,Cao-Qi Lei,Qing Yang,Wei-Wei Luo,Shu Li,Hong-Bing Shu +12 more
TL;DR: It is demonstrated that ZCCHC3 is a co‐receptor for RLRs, thereby acting as an important modulator of innate antiviral response.
114
TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses
Qing Yang,Tian-Tian Liu,Heng Lin,Man Zhang,Jin Wei,Wei-Wei Luo,Yun-Hong Hu,Bo Zhong,Ming-Ming Hu,Hong-Bing Shu +9 more
TL;DR: The authors showed that deficiency of the E3 ubiquitin ligase TRIM32 increases poly(I:C)-and LPS-induced transcription of downstream genes such as type I interferons (IFNs) and proinflammatory cytokines in both primary mouse immune cells and in mice.
ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
Huan Lian,Jin Wei,Ru Zang,Wen Ye,Qing Yang,Xia-Nan Zhang,Yun-Da Chen,Yu-Zhi Fu,Ming-Ming Hu,Cao-Qi Lei,Wei-Wei Luo,Shu Li,Hong-Bing Shu +12 more
TL;DR: This work identifies ZCCHC3, a CCHC-type zinc-finger protein, as a positive regulator of cytosolic dsDNA- and DNA virus-triggered signaling and suggests it is important for cGAS activation following viral infection.
SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA.
Jin Wei,Huan Lian,Wei Guo,Yun-Da Chen,Xia-Nan Zhang,Ru Zang,Li Zhong,Qing Yang,Ming-Ming Hu,Wei-Wei Luo,Hong-Bing Shu,Shu Li +11 more
TL;DR: Snx8-/- mice infected with the DNA virus HSV-1 exhibited lower serum cytokine levels and higher viral titers in the brains, resulting in higher lethality, suggesting that SNX8 is a critical component in innate immune response to cytosolic DNA and DNA virus.