Wei Wei
University of Oxford
3 Papers
Wei Wei is an academic researcher from University of Oxford. The author has contributed to research in topics: In vitro & In vivo. The author has co-authored 3 publications.
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Papers
Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer.
Wei Wei,Y. Zhou,Zhanzhan Feng,Xiaolei Zhang,Liu Zhihao,Xinyue Li,Hualong He,Kai Ran,Yaojie Shi,Yongxia Zhu,Tinghong Ye,Chao Gao,Ning-Yu Wang,Luoting Yu +13 more
TL;DR: Wang et al. as mentioned in this paper described the discovery of FAK inhibitors using a scaffold hopping strategy, which exhibited inhibitory activities against FAK signaling in vitro, and no obvious adverse effects were observed during the in vivo study.
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Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine derivatives as potent fibroblast growth factor receptor inhibitors
TL;DR: A series of 1H-pyrrolo[2,3-b]pyridine derivatives with potent activities against FGFR1, 2, and 3 exhibited potent FGFR inhibitory activity in vitro, and compound 4h with low molecular weight would be an appealing lead compound which was beneficial to the subsequent optimization.
Synthesis and biological evaluation of indazole derivatives as anti-cancer agents
Wei Wei,Liu Zhihao,Xiuli Wu,Cailing Gan,Xingping Su,Hongyao Liu,Hanyun Que,Qianyu Zhang,Qiang Xue,Lin Yue,Luoting Yu,Tinghong Ye +11 more
TL;DR: 2f had potent growth inhibitory activity against several cancer cell lines and could suppress the growth of the 4T1 tumor model without obvious side effects in vivo, identified as a potential small molecule anti-cancer agent.