7 Papers
11 Citations
Wei Wei is an academic researcher from Fujian University of Traditional Chinese Medicine. The author has contributed to research in topics: Kinase & Apoptosis. The author has an hindex of 4, co-authored 7 publications.
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Papers
The effect of swimming exercise and diet on the hypothalamic inflammation of ApoE-/- mice based on SIRT1-NF-κB-GnRH expression
Xialei Wang,Jingda Yang,Taotao Lu,Zengtu Zhan,Wei Wei,Xinru Lyu,Yijing Jiang,Xiehua Xue +7 more
- 09 Jun 2020
TL;DR: The hypothesis that hypothalamic inflammation was susceptible to exercise and diet, which was strongly associated with SIRT1-NF-κB-GnRH expression in the hypothalamus, was supported.
Proliferation of Vascular Smooth Muscle Cells under ox-LDL Is Regulated by Alismatis rhizoma Decoction via InhibitingERK1/2 and miR-17∼92a Cluster Activation.
TL;DR: The results provide the multitarget mechanisms for application of AD in the treatment of atherosclerosis and reduce the expression of MMP-2/9 in VSMCs through inhibiting ERK1/2 and miR-17∼92a activation.
Inhibition of ERK1/2 improves lipid balance in rat macrophages via ABCA1/G1 and CD36
TL;DR: Investigation of the effects of extracellular signal-regulated kinases 1/2 (ERK1/2) inhibition on lipid balance in oxidized-low-density lipoprotein (Ox-LDL)-stimulated rat macrophages indicated a novel association between ERK1 /2 signaling and lipid metabolism, thus suggesting that inhibition of ERK2/2 may be considered a promising therapeutic strategy against AS.
[Effect of alisol A 24-acetate on proliferation of aorta smooth muscle cells in rats induced by ox-LDL].
TL;DR: Alisol A 24-acetate can inhibit the proliferation of VSMCs induced by ox-LDL and the mechanism may be associated with inhibiting expression of cyclin protein, including cyclinD1, cyclinE, p21, p27 and so on.
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Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells
TL;DR: The findings suggest that blocking lipid deposition and inhibiting inflammatory response through the activation of the LXRα pathway may be one of the main mechanisms through which AD exerts its anti-atherosclerotic effects.