6 Papers
14 Citations
Wei Wang is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Endosome & LDL receptor. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Wei Wang include University of Helsinki.
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Papers
NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.
Vilja Pietiäinen,Boris Vassilev,Boris Vassilev,Tomas Blom,Tomas Blom,Wei Wang,Wei Wang,Jessica K. Nelson,Robert Bittman,Nils Bäck,Noam Zelcer,Elina Ikonen,Elina Ikonen +12 more
TL;DR: It is reported that NDRG1 silencing in epithelial cells results in decreased uptake of low-density lipoprotein (LDL) due to reduced LDL receptor (LDLR) abundance at the plasma membrane, and co-depletion of IDOL, which ubiquitylates the LDLR and promotes its degradation, rescues plasma membrane LDLR levels and LDL uptake.
Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2
Wei Wang,Aino-Liisa Mutka,Ursula Prosenc Zmrzljak,Damjana Rozman,Heikki Tanila,Helena Gylling,Anne M. Remes,Henri J. Huttunen,Elina Ikonen +8 more
TL;DR: The results show that APP regulates cholesterol metabolism in cells relevant for whole‐body cholesterol balance and reveal that APP α‐and β‐cleavages produce opposing paracrine regulators of SREBP2 signaling.
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Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl esters.
TL;DR: Dehydroepiandrosterone-fatty acyl esters (DHEA-FAE) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives that are transported in circulating lipoproteins and may...
14
The central role of GmGLP20.4 in root architecture modifications of soybean under low-nitrogen stress
Wei Wang,Jiajia Li,Muhammad Nadeem,Jianxin Wang,Ru Huang,Qian Liu,Wenqiao Fan,Long Yan,Xiaobo Wang +8 more
TL;DR: GmGLP20.4 is involved in soybean root development and the natural variation of its promoter will be useful in modern intercropping systems or to improve nitrogen-use efficiency.
8
What dictates the accumulation of desmosterol in the developing brain
Maurice Jansen,Wei Wang,Dario Greco,Gian Carlo Bellenchi,Umberto di Porzio,Andrew J. Brown,Elina Ikonen +6 more
TL;DR: It is proposed that desmosterol accumulation in the developing brain may be primarily caused by post‐transcriptional repression of 3β‐hydroxysterol 24‐reductase (DHCR24) by progesterone, and regulated accumulation of des mosterol by progestersone‐induced suppression of DHCR24 may facilitate the rapid enrichment and distribution of membrane sterols in the developed brain.