African swine fever - A review of current knowledge.

https://digital.csic.es/bitstream/10261/215625/1/Pool_Goatley_Art2020.pdf

A Pool of Eight Virally Vectored African Swine Fever Antigens Protect Pigs Against Fatal Disease.

African swine fever (ASF) is a viral disease with a high fatality rate in both domestic pigs and wild boars. ASF has greatly challenged pig-raising countries and also negatively impacted regional and national trade of pork products. To date, ASF has spread throughout Africa, Europe, and Asia. The development of safe and effective ASF vaccines is urgently required for the control of ASF outbreaks. The ASF virus (ASFV), the causative agent of ASF, has a large genome and a complex structure. The functions of nearly half of its viral genes still remain to be explored. Knowledge on the structure and function of ASFV proteins, the mechanism underlying ASFV infection and immunity, and the identification of major immunogenicity genes will contribute to the development of an ASF vaccine. In this context, this paper reviews the available knowledge on the structure, replication, protein function, virulence genes, immune evasion, inactivation, vaccines, control, and diagnosis of ASFV.

/pdf/african-swine-fever-virus-a-review-2p0qaceh.pdf

African Swine Fever Virus: A Review

Impacts of COVID-19 pandemic on the wastewater pathway into surface water: A review.

Significance African swine fever virus (ASFV) causes a severe and highly contagious disease in pigs and wild boars, but no commercial vaccines or antivirals are available currently. Understanding the mutual antagonism between virus and host factors during ASFV infection may facilitate the development of new vaccines and antivirals. Our work profiled transcriptomes of swine macrophages infected with ASFV through single-cell RNA-sequencing technology. Identified dynamic transcriptome events of viral genes provide molecular characteristics of ASFV during infection. Moreover, virus–host interactions imply the regulation pathway of viral replication in host cells, which may guide research on antiviral strategies and dissection of ASFV pathogenesis.

Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution

Cryo-EM Structure of the African Swine Fever Virus

Efficient inactivation of African swine fever virus by ozonized water.

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Cryo-EM Structure of the African Swine Fever Virus

Efficient inactivation of African swine fever virus by ozonized water.