6 Papers
31 Citations
Wei Tang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Wnt signaling pathway & LRP6. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Wei Tang include University of Texas at Dallas & University of Texas System.
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Papers
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Baozhi Chen,Michael E. Dodge,Wei Tang,Jianming Lu,Zhiqiang Ma,Chih Wei Fan,Shuguang Wei,Wayne Hao,Jessica A. Kilgore,Noelle S. Williams,Michael G. Roth,James F. Amatruda,Chuo Chen,Lawrence G. Lum +13 more
TL;DR: Two novel classes of small molecules are discovered that disrupt Wnt pathway responses and contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals.
1.4K
A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
Wei Tang,Michael E. Dodge,Deepika Gundapaneni,C. H. Michnoff,Michael G. Roth,Lawrence G. Lum +5 more
TL;DR: Surprisingly, it is found that the presumed cancer-promoting gene TCF7L2 functions instead as a transcriptional repressor that restricts colorectal cancer (CRC) cell growth.
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Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.
Leni S. Jacob,Xiaofeng Wu,Michael E. Dodge,Chih Wei Fan,Ozlem Kulak,Baozhi Chen,Wei Tang,Baolin Wang,James F. Amatruda,Lawrence G. Lum +9 more
TL;DR: It is found that Stk11 loss resulted in disassembly of the primary cilium, a cellular organizing center for Hh pathway components, thus dampening Hh signaling, and this approach provides a platform to support the development of targeted therapeutic strategies.
Patent
Wnt protein signalling inhibitors
Lawrence G. Lum,Michael Roth,Baozhi Chen,Chuo Chen,Michael E. Dodge,Wei Tang +5 more
- 27 May 2009
TL;DR: In this paper, compounds that inhibit the Wnt protein signalling pathway are disclosed and used in the treatment of Wnt-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
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The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation
Chih Wei Fan,Baozhi Chen,Irene Franco,Jianming Lu,Heping Shi,Shuguang Wei,Chang-Guang Wang,Xiaofeng Wu,Wei Tang,Michael G. Roth,Noelle S. Williams,Emilio Hirsch,Chuo Chen,Lawrence G. Lum +13 more
TL;DR: It is demonstrated that Smo supplied with a synthetic agonist or activated with oncogenic mutations can signal without ciliary accumulation, and that cells with compromised ciliary Smo trafficking due to loss of the phosphatidylinositol-4-phosphate 3-kinase (PI3K)-C2α retain transcriptional response to an exogenously supplied Smo agonist.
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