Wei Shu

TL;DR: The optimization of a chemical series representing a new class of PRC2 inhibitors which acts allosterically via the trimethyllysine pocket of the noncatalytic EED subunit is described.

TL;DR: In this article, the authors provided quinazoline compounds that are inhibitors of PDKl and pharmaceutical compositions including the compounds, and methods of treating proliferative diseases such as cancers, with the compounds or compositions.

TL;DR: The discovery and optimization of a series of 4-(aminomethyl)quinolin-2(1H)-ones, exemplified by 34, that inhibit bacterial DNA gyrase and topoisomerase IV and display potent activity against ciprofloxacin-resistant Gram-negative pathogens are described.

TL;DR: The identification and synthesis of novel LpxC inhibitors aided by computational methods that leveraged numerous crystal structures led to the identification of oxazolidinone and isoxazoline inhibitors with potent in vitro activity against P. aeruginosa and other Gram-negative bacteria.