Wei Shen
Pfizer
5 Papers
34 Citations
Wei Shen is an academic researcher from Pfizer. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 3 publications.
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Papers
Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.
Katrina L. Paumier,Stacey J. Sukoff Rizzo,Zdenek Berger,Yi Chen,Cathleen Gonzales,Edward Kaftan,Li Li,Susan M. Lotarski,Michael Monaghan,Wei Shen,Polina Stolyar,Dmytro Vasilyev,Margaret M. Zaleska,Warren D. Hirst,John Dunlop +14 more
TL;DR: Results from open field and rotarod tests show A53T mice develop age-dependent changes in locomotor activity and reduced anxiety-like behavior, and digigait analysis shows these mice develop an abnormal gait by 12 months of age, which may provide useful endpoints for assessing novel therapeutic interventions for PD.
Human A53T α-Synuclein Causes Reversible Deficits in Mitochondrial Function and Dynamics in Primary Mouse Cortical Neurons
Li Li,Sashi Nadanaciva,Zdenek Berger,Wei Shen,Katrina L. Paumier,Joel W. Schwartz,Kewa Mou,Paula Loos,Anthony J. Milici,John Dunlop,Warren D. Hirst +10 more
TL;DR: It is demonstrated that A53T α-syn impairs mitochondrial function and dynamics and the deficit of mitochondrial transport is reversible, providing further understanding of the disease pathogenesis and a potential therapeutic strategy for PD.
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Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons.
Wei Shen,Anastasia G. Henry,Katrina L. Paumier,Li Li,Kewa Mou,John Dunlop,Zdenek Berger,Warren D. Hirst +7 more
TL;DR: The findings demonstrate a direct link between glycosphingolipid biosynthesis and autophagy in primary neurons, which may represent a novel pathway with potential therapeutic value for the treatment of Parkinson's disease.
35
Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus
Yi Yan,Mengye Zhu,X. Cao,Gang Xu,Wei Shen,Fan Li,Jinjin Zhang,L. Luo,Xuexue Zhang,Dayi Zhang,Tao Li +10 more
TL;DR: In this paper , the authors showed that the activation of VPL TC neurons potentiates excitatory synaptic transmission to the hindlimb region of the primary somatosensory cortex (S1HL) as well as mechanical hypersensitivity following spared nerve injury (SNI)-induced neuropathic pain in mice.
CaMKIIα neurons in the anterior insular cortex regulate attention behavior in mice
Yingping Ma,Shaofei Jiang,Xin Zhao,Shen Li,Liping Chen,Zhe Zhao,Wei Shen,Yangjie Wu,Haitao Wu +8 more
TL;DR: In this paper , the role of the anterior insular cortex (aIC) in visuospatial attention and impulsiveness in mice was assessed using the 5-choice serial reaction time task (5-CSRTT) testing paradigm.