Wei Sang
12 Papers
Wei Sang is an academic researcher. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 5, co-authored 9 publications.
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Papers
Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy.
Lisi Xie,Jie Li,Guohao Wang,Wei Sang,Mengze Xu,Wenxi Li,Jie Yan,Bei Li,Zhan Zhang,Qi Zhao,Zhen Yuan,Quli Fan,Yu-ping Dai +12 more
TL;DR: This novel synergy of PTT with antiexosomal PD-L1 enhanced ferroptosis evoked potent antitumor immunity in B16F10 tumors and immunological memory against metastatic tumors in lymph nodes.
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Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy
Hao Tian,Guohao Wang,Wei Sang,Lisi Xie,Zhan Zhang,Wenxi Li,Jie Yan,Ye Tian,Jie Li,Bei Li,Yu-ping Dai +10 more
TL;DR: In this article , a phenolic nanoadjuvant was developed by self-assembly of the sonosensitizer polymer (PEG-b-IR), GSH inhibitor (sabutoclax), Mn2+ and TME acidic sensitive phenolic polymer via metal-phenolic coordination.
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A Metal-Phenolic Nanosensitizer Performs Hydrogen Sulfide-Reprogrammed Oxygen Metabolism for Cancer Radiotherapy Intensification and Immunogenicity.
Jie Li,Lisi Xie,Wei Sang,Wenxi Li,Guohao Wang,Jie Yan,Zhan Zhang,Hao Tian,Quli Fan,Yu-ping Dai +9 more
TL;DR: A metal-phenolic nanosensitizer was integrated by an acid-sensitive hydrogen sulfide donor and generated H2S to reduce cellular oxygen consumption rate via mitochondrial respiration inhibiting, which reprogrammed oxygen metabolism for tumor oxygenation improvement.
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A Metal–Phenolic Nanocoordinator Launches Radiotherapeutic Cancer Pyroptosis Through an Epigenetic Mechanism
Guohao Wang,Bei Li,Hao Tian,Lisi Xie,Jie Yan,Wei Sang,Jie Li,Zhan Zhang,Wenxi Li,Yu-ping Dai +9 more
TL;DR: In this article , an epigenetic strategy to launch cancer pyroptosis in radiotherapy is introduced, where the nanocoordinator (PWE) is constructed via a metal-phenolic coordination between polyphenolic DNA methyltransferase inhibitor (epigallocatechin−3−gallate, EGCG), high-Z radiosensitizer (W6+), and polyphenol modified block copolymer.
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A Triple‐Kill Strategy for Tumor Eradication Reinforced by Metal‐Phenolic Network Nanopumps
TL;DR: Clinical/preclinical materials and approaches are employed as foundations and innovatively incorporate AHSC NPs to furnish a research basis and reference value for the integration of nanotechnology into clinical trials.
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