Wei Rui
Chinese Academy of Sciences
8 Papers
Wei Rui is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Oxidative stress & Reactive oxygen species. The author has an hindex of 8, co-authored 8 publications.
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Papers
PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells
TL;DR: The results suggest the possibility that PM2.5-induced oxidative stress probably plays a key role in autophagy in A549 cells, which may contribute to PM3.0-induced impairment of pulmonary function.
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PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells.
TL;DR: PM2.5-induced ROS may function as signaling molecules to activate Nrf2-mediated defenses, such as HO-1 expression, against oxidative stress induced by PM2.
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PM2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through the ERK/AKT/NF-κB-dependent pathway.
TL;DR: Findings suggest PM2.5‐induced ROS may function as signaling molecules triggering ICAM‐1 and VC AM‐1 expressions through activating the ERK/AKT/NF‐κB‐dependent pathway, and further promoting monocyte adhesion to endothelial cells.
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Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells
TL;DR: Novel insights are provided into the mechanism of cytotoxicity and even pathogenesis of diseases associated with PM2.5 exposure and reactive oxygen species (ROS) function as signaling molecules for all the three pathways.
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Direct effects of airborne PM2.5 exposure on macrophage polarizations.
TL;DR: It is suggested that short-term exposure of PM2.5 acts on the balance of inflammatory M1 and anti-inflammatory M2 macrophage polarizations, which may be involved in air pollution-induced immune disorders and diseases.
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