Wei Qin
Peking University
23 Papers
10 Citations
Wei Qin is an academic researcher from Peking University. The author has contributed to research in topics: Biology & Proteome. The author has an hindex of 9, co-authored 18 publications. Previous affiliations of Wei Qin include Beijing Institute of Technology & Chinese Ministry of Education.
Chat about Author
Papers
Deciphering molecular interactions by proximity labeling.
TL;DR: Proximity labeling (PL) is a technique for tagging the endogenous interaction partners of specific protein "baits" via genetic fusion to promiscuous enzymes that catalyze the generation of diffusible reactive species in living cells as discussed by the authors.
374
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate.
Wei Qin,Ke Qin,Y. Zhang,Wentong Jia,Ying Chen,Bo Cheng,Linghang Peng,Nan Chen,Yuan Liu,Wen Zhou,Yan-Ling Wang,Xing Chen,Chu Wang +12 more
TL;DR: This study developed a specific thiol-reactive probe, 1-OH-Az, for quantitative chemoproteomic profiling of cysteine modifications by itaconate, and provided a global portrait of its proteome reactivity, finding that itaconates covalently modifies key glycolytic enzymes and impairs gly colytic flux mainly through inhibition of fructose-bisphosphate aldolase A (ALDOA).
237
Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.
Wei Qin,Ke Qin,Xinqi Fan,Linghang Peng,Weiyao Hong,Yuntao Zhu,Pinou Lv,Yifei Du,Rongbing Huang,Mengting Han,Bo Cheng,Yuan Liu,Wen Zhou,Chu Wang,Xing Chen +14 more
TL;DR: It is demonstrated that the use of unacetylated unnatural sugars can avoid the artifact formation and a corrected list of O- GlcNAcylated proteins and O-GlcNAc sites in HeLa cells has been assembled by using N-azidoacetylgalactosamine (GalNAz).
171
Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe
Ying Chen,Yuan Liu,Tong Lan,Wei Qin,Yuntao Zhu,Ke Qin,Jinjun Gao,Haobo Wang,Xiaomeng Hou,Nan Chen,José Pedro Friedmann Angeli,Marcus Conrad,Chu Wang +12 more
TL;DR: A quantitative chemoproteomic method to profile carbonylations in ferroptosis by an aniline-derived probe is developed and a novel cysteine site of modification on voltage-dependent anion-selective channel protein 2 (VDAC2) is discovered that might play an important role in sensitizing LDE signals and mediating ferroPTosis.
157
Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.
TL;DR: 1,3-di-esterified N-azidoacetylgalactosamine (GalNAz) is developed as next-generation chemical reporters for metabolic glycan labeling and it is shown that ESRRB O-GlcNAcylation is important for mESC self-renewal and pluripotency.