Wei Q. Jiao
Jilin University
6 Papers
1 Citations
Wei Q. Jiao is an academic researcher from Jilin University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Application of Counter-Current Solvent Extraction to the Separation of Naphthalene and Nonionic Surfactants
TL;DR: In this article, the influence of solvent/solution volumetric ratio, solvent flow rate, and surfactant concentration on counter-current solvent extraction efficiency was investigated, and fitting formulas for predicting the partition coefficients of the contaminant between the aqueous and solvent phases were developed.
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Evidence for cytochrome P450 3A4-mediated metabolic activation of SCO-267.
Cui Li,Xiaokun Li,Ali Fan,Ning He,Dongmei Wu,Hongyan Yu,Kun Wang,Wei Q. Jiao,Xu Zhao +8 more
TL;DR: Investigation of the bioactivation potential of SCO-267 in vitro and in vivo revealed that SCO-267 undergoes a facile CYP3A4-catalyzed bioactivation with the generation of quinone-imine and ortho-quinone intermediates, which were assumed to be involved in SCO-267 induced CYP3A inactivation.
A simple and sensitive liquid chromatography triple quadrupole mass spectrometry method for the determination of XL092 in monkey plasma and its application to pharmacokinetic study.
Cui Li,Xiaokun Li,Ali Fan,Ning He,Dongmei Wu,Hongyan Yu,Kun Wang,Wei Q. Jiao,Xu Zhao +8 more
TL;DR: The validated method was demonstrated to be selective, sensitive, and reliable, and has been successfully applied to the pharmacokinetic study of XL092 in monkey plasma.
Simultaneous determination of sinomenine and its metabolites desmethyl-sinomenine and sinomenine N-oxide in rat plasma by liquid chromatography tandem mass spectrometry.
Ning He,Ali Fan,Dongmei Wu,Hongyan Yu,Kun Wang,Wei Q. Jiao,Xu Zhao +6 more
TL;DR: The results suggested that sinomenine was rapidly metabolized into its metabolite desmethyl sinomenine and sinomenine N-oxide in rat plasma after oral administration of sinomenine at a single dose of 5 mg/kg.
Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents.
TL;DR: In this article , the anti-AIS activity of R- and S-FMPB generated from hybridization of ring-opened R-and S-3-N-butylphthalide derivatives with 4-fluro-edaravone (4-F-Eda) was reported.