Wei Pan
University of Pennsylvania
8 Papers
52 Citations
Wei Pan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Notch signaling pathway & Progenitor cell. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Wei Pan include University of Florida & University of Rochester Medical Center.
Chat about Author
Papers
The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression
Zinan Zhou,David R. Rawnsley,Lauren M. Goddard,Wei Pan,Xing Jun Cao,Zoltán Jakus,Hui Zheng,Jisheng Yang,J. Simon C. Arthur,Kevin J. Whitehead,Dean Y. Li,Dean Y. Li,Bin Zhou,Benjamin A. Garcia,Xiangjian Zheng,Xiangjian Zheng,Mark L. Kahn +16 more
TL;DR: It is shown that loss of CCM signaling in endocardial cells results in mid-gestation heart failure associated with premature degradation of cardiac jelly, and the findings reveal a molecular mechanism by whichCCM signaling controls endothelial gene expression during cardiovascular development that may also underlie CCM formation.
160
Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.
TL;DR: In this paper , the latest advancement in the development of DDR kinase inhibitors including those in preclinical stages and clinical trials, the crystal structures of DDR enzymes, and binding modes of inhibitors with target proteins are summarized.
80
Calcium-regulated Phosphorylation of Soybean Serine Acetyltransferase in Response to Oxidative Stress
Fenglong Liu,Byung-Chun Yoo,Byung-Chun Yoo,Jung-Youn Lee,Jung-Youn Lee,Wei Pan,Alice C. Harmon +6 more
TL;DR: Results support the hypothesis that GmSerat2;1 is regulated by calcium-dependent protein kinase phosphorylation in vivo and suggest that increased Gm Serat 2;1 synthesis and phosphorylated in response to active oxygen species could play a role in anti-oxidative stress response.
53
Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.
Grace Savoy-Burke,Felicia Gilels,Wei Pan,Diana Pratt,Jianwen Que,Lin Gan,Patricia M. White,Amy E. Kiernan +7 more
TL;DR: The data show that Notch signaling inhibits hair cell differentiation and promotes a supporting cell-like phenotype, and that these effects are unlikely to be mediated by SOX2.
Potent Inhibition of Human Cytochrome P450 3A4 by Biflavone Components from Ginkgo Biloba and Selaginella Tamariscina
Bo Wang,Chao Shi,Lei Feng,Wei Pan,Xiangge Tian,Cheng-Peng Sun,Chao Wang,Jing Ning,Xia Lv,Yan Wang,Qian-Hui Yuan,Rui-Xuan Guan,Hou-Li Zhang,Xiaochi Ma,Tongling Ma +14 more
TL;DR: The results suggest the potential pharmacokinetic interactions between the identified biflavones and clinical drugs undergoing CYP3A4-mediated biotransformation and the obtained information is important for guiding the rational use of herbal medicine in combination with synthetic pharmaceuticals.