10 Papers
4 Citations
Wei Ni is an academic researcher from East China University of Science and Technology. The author has contributed to research in topics: Chemistry & Acetylcholinesterase. The author has an hindex of 6, co-authored 8 publications.
Chat about Author
Papers
Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents
Xiaokang Li,Huan Wang,Zhengyu Lu,Xinyu Zheng,Wei Ni,Jin Zhu,Yan Fu,Fulin Lian,Naixia Zhang,Jian Li,Hai-Yan Zhang,Fei Mao +11 more
TL;DR: Compound 5r displayed appropriate blood-brain barrier permeability both in vitro and in vivo and could improve memory and cognitive function of scopolamine-induced amnesia mice and highlight these structurally distinct pyrimidinylthiourea derivatives as prospective prototypes in the research of innovative multifunctional drugs for Alzheimer's disease.
75
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer’s Disease
Fei Mao,Huan Wang,Wei Ni,Xinyu Zheng,Manjiong Wang,Keting Bao,Dazheng Ling,Xiaokang Li,Yixiang Xu,Hai-Yan Zhang,Jian Li +10 more
TL;DR: 1w·Cit (citrate of 1w) could reverse the cognitive dysfunction of scopolamine-induced AD mice and exhibited an excellent effect on enhancing cAMP response element-binding protein (CREB) phosphorylation in vivo, a crucial factor in memory formation and synaptic plasticity.
56
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).
Wei Ni,Huan Wang,Xiaokang Li,Xinyu Zheng,Manjiong Wang,Jian Zhang,Qi Gong,Dazheng Ling,Fei Mao,Hai-Yan Zhang,Jian Li +10 more
TL;DR: Among the 19 analogues, compound 3c exhibited good selective dual-target AChE/PDE5 inhibition and good blood-brain barrier (BBB) permeability, and possessed improved water solubility and good effects against scopolamine-induced cognitive impairment with inhibition of cortical A ChE activities and enhancement of cAMP response element-binding protein (CREB) phosphorylation ex vivo.
22
HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes
Chenlu Song,Yiqiu Zhang,Qing-guo Pei,Li Zheng,Meiyu Wang,You-Zhen Shi,Shan Wu,Wei Ni,Xiu-Jun Fu,Yinbo Peng,Wen Zhang,Min Yao +11 more
TL;DR: In this paper , the authors investigated whether heat shock proteins (HSPs) can attenuate cellular mitochondrial dysfunction, exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.
16
A Metal-Free Approach to 3-Aryl-3-hydroxy-2-oxindoles by Treatment of 3-Acyloxy-2-oxindoles with Diaryliodonium Salts.
TL;DR: In this article, a mild metal-free approach has been realized for the facile construction of highly valuable 3-(hetero)aryl-3-hydroxy-2-oxindoles.
3