Wei Mo
Fudan University
11 Papers
76 Citations
Wei Mo is an academic researcher from Fudan University. The author has contributed to research in topics: Pichia pastoris & Fusion protein. The author has an hindex of 6, co-authored 11 publications. Previous affiliations of Wei Mo include Chinese Ministry of Education.
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Papers
Codon optimization, expression, purification, and functional characterization of recombinant human IL-25 in Pichia pastoris
TL;DR: A new strategy for the large-scale production of bioactive IL-25 for biological and therapeutic applications is provided and functional analysis showed that purified rhIL-25 specifically bond to receptor IL-17BR and induce G-CSF production in vitro.
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer
TL;DR: The engagement of the PD-1/PD-L1 blockade to c-Met-overexpressing cancer cells is a promising strategy for the treatment of gastric cancer and potentially other malignancies.
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Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following FcεRI Aggregation
TL;DR: Signaling regulatory mechanism investigation using immunoblotting, immunoprecipitation, and GST pull-down assay reveals that the down-regulation of Shp2 expression in RBL cells leads to decreased activities of Fyn, PLCγ, JNK, p38MAPK, and Ras/Erk1/2 after FcεRΙ aggregation.
Bromodomain-containing protein 2 promotes lipolysis via ERK/HSL signalling pathway in white adipose tissue of mice.
TL;DR: This study provides the first evidence that adenoviral-mediated Brd2 overexpression in the WAT of mice increases lipolysis-related gene expression in addition to significantly reducing WAT size and promoting plasma FFA release.
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Generation and Characterization of a Bispecific Antibody Targeting Both PD-1 and c-MET
TL;DR: The results indicated that a novel BsAb recognizing PD-1 and c-MET was successfully generated and could redirect T cells to kill tumor cells, while retaining its inherent ability to restore T cells and inhibit tumor cells.
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