11 Papers
1 Citations
Wei Lin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Metastasis & microRNA. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Wei Lin include University of Texas Health Science Center at Houston.
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Papers
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Limo Chen,Don L. Gibbons,Sangeeta Goswami,Maria Angelica Cortez,Young Ho Ahn,Lauren Averett Byers,Xuejun Zhang,Xiaohui Yi,David Dwyer,Wei Lin,Lixia Diao,Jing Wang,Jonathon D. Roybal,Mayuri Patel,Christin Ungewiss,David H. Peng,Scott J. Antonia,Melanie Mediavilla-Varela,Gordon Robertson,Steve Jones,Milind Suraokar,James W. Welsh,Baruch Erez,Ignacio I. Wistuba,Lieping Chen,Di Peng,Shanshan Wang,Stephen E. Ullrich,John V. Heymach,Jonathan M. Kurie,F. Xiao Feng Qin,F. Xiao Feng Qin +31 more
TL;DR: A molecular link between epithelial-to-mesenchymal transition (EMT) and CD8+ TIL immunosuppression and cancer progression is demonstrated and ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists.
The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice
Yanan Yang,Young Ho Ahn,Don L. Gibbons,Yi Zang,Wei Lin,Nishan Thilaganathan,Cristina A. Alvarez,Daniel C. Moreira,Chad J. Creighton,Philip A. Gregory,Gregory J. Goodall,Jonathan M. Kurie +11 more
TL;DR: What is believed to be a novel Jagged2/miR-200-dependent pathway that mediates lung adenocarcinoma EMT and metastasis in mice is revealed and may have implications for the treatment of human epithelial tumors.
Dysregulation of Cell Polarity Proteins Synergize with Oncogenes or the Microenvironment to Induce Invasive Behavior in Epithelial Cells
Samit Chatterjee,Samit Chatterjee,Laurie A. Seifried,Michael E. Feigin,Don L. Gibbons,Claudio Scuoppo,Wei Lin,Zain H. Rizvi,Evan F. Lind,Dilan Dissanayake,Jonathan M. Kurie,Pamela S. Ohashi,Senthil K. Muthuswamy,Senthil K. Muthuswamy +13 more
TL;DR: It is demonstrated that loss of polarity proteins confers phenotypic plasticity to epithelial cells such that they display normal behavior under normal culture conditions but display aggressive behavior in response to activation of oncogenes or exposure to cytokines.
Regulation of tumor cell PD-L1 expression by microRNA-200 and control of lung cancer metastasis.
Don L. Gibbons,Limo Chen,Sangeeta Goswami,Maria Angelica Cortez,Young Ho Ahn,Lauren Averett Byers,Wei Lin,Lixia Diao,Jing Wang,Jonathon D. Roybal,Christin Ungewiss,Scott J. Antonia,Melanie Mediaville-Varela,Milind Suraokar,James W. Welsh,Lieping Chen,Ignacio I. Wistuba,John V. Heymach,Jonathan M. Kurie,Frank Xiao-Feng Qin +19 more
TL;DR: It is shown that tumor cell regulation of the activity of diverse inflammatory cells creates an immunosuppressive microenvironment that favors tumor growth and metastasis and the mechanistic justification for this preference is unclear.
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Polycrystalline ZSM-5@Beta core–shell composites fabricated by a seed-directed approach: A catalyst to boosting light olefin production by ordered hierarchical cracking
Lei Han,Ruoyu Wang,Peng Wang,Yu Fang Sha,Aiguo Zheng,Qiuqiao Jiang,Mudi Xin,Haitao Song,Wei Lin +8 more
TL;DR: In this paper , a novel embryo seed-breeding (ESB) approach was developed to synthesize polycrystalline [email protected] core-shell composites for boosted light olefin production.
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