Wei Li
University of Toronto
18 Papers
162 Citations
Wei Li is an academic researcher from University of Toronto. The author has contributed to research in topics: Trophoblast & Placenta. The author has an hindex of 13, co-authored 17 publications. Previous affiliations of Wei Li include Lunenfeld-Tanenbaum Research Institute & Canadian Institutes of Health Research.
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Papers
Late Gestation Increase in 11β-Hydroxysteroid Dehydrogenase 1 Expression in Human Fetal Membranes: A Novel Intrauterine Source of Cortisol
TL;DR: It is suggested that increases in 11beta-HSD 1 expression/activity by intrauterine membranes during late gestation may result in increased potential for a local increase in F production and that FM should be considered as an extraadrenal source of F duringLate gestation.
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Fetal signals and parturition.
John R. G. Challis,Frank H. Bloomfield,Frank H. Bloomfield,Alan D. Bocking,Valentina Casciani,Hiroshi Chisaka,Kristin L. Connor,Xuesen Dong,Xuesen Dong,Peter D. Gluckman,Jane E. Harding,JF Johnstone,Wei Li,Stephen J. Lye,Stephen J. Lye,Kunihiro Okamura,M Premyslova +16 more
TL;DR: This research presents a novel and scalable approach to providing real-time information about the development and health of fetuses through the first trimester of pregnancy and the first three months of lactation.
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Corticotropin-releasing hormone and urocortin induce secretion of matrix metalloproteinase-9 (MMP-9) without change in tissue inhibitors of MMP-1 by cultured cells from human placenta and fetal membranes.
Wei Li,John R. G. Challis +1 more
TL;DR: The results suggest that CRH and Ucn may play a role in the mechanisms controlling human parturition and preterm delivery not only by affecting myometrial contractility, but also by increasing local MMP activity in placenta and fetal membranes, thereby contributing to membrane rupture with the onset and progression of human labor.
Tumor Necrosis Factor Stimulates Matrix Metalloproteinase 9 Secretion from Cultured Human Chorionic Trophoblast Cells Through TNF Receptor 1 Signaling to IKBKB-NFKB and MAPK1/3 Pathway
TL;DR: It is demonstrated that TNF stimulates proMMP9 production in CT cells through TNFRSF1A-TRAFs-IKBKB-NFKB and ERK signaling pathways, but not through TNSF1B and JNK/p38-AP-1 pathways.
Expression of extracellular matrix metalloproteinase inducer in human placenta and fetal membranes at term labor.
TL;DR: It is concluded that human placenta and fetal membranes express EMMPRIN, with the potential to stimulate MMP production, thereby facilitating fetal membrane rupture and leading to detachment of the placento- fetal membranes from the maternal uterus at the time of parturition.
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