Wei Li
Duquesne University
7 Papers
109 Citations
Wei Li is an academic researcher from Duquesne University. The author has contributed to research in topics: Dihydrofolate reductase & Thymidylate synthase. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Wei Li include Tufts University.
Chat about Author
Papers
Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine Antifolates
TL;DR: This study indicated that the 5-substituted 2-amino-4-oxo-6-methylthieno[2,3-d]pyrimidine scaffold is highly conducive to dual human TS-DHFR inhibitory activity.
Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents
TL;DR: Compound 2 was an excellent dual inhibitor of human TS and human DHFR and afforded nanomolar GI50 values against tumor cells in culture and X-ray crystal structures of 2 and 1 showed for the first time that the thieno[2,3-d]pyrimidine ring binds in a "folate" mode.
Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.
TL;DR: The nonclassical analogues were marginal inhibitors of human TS, but four analogues showed potent T. gondii DHFR inhibition along with >100-fold selectivity compared to human DHFR.
54
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Aleem Gangjee,Wei Li,Lu Lin,Yibin Zeng,Michael A. Ihnat,Linda A. Warnke,Dixy W. Green,Vivian Cody,Jim Pace,Sherry F. Queener +9 more
TL;DR: Inhibition of EGFR and PDGFR-beta were discovered for saturated C9-homologated analogs 9 and 10 that were absent in the saturated C8-C9 unsaturated compounds 2-7 and catalytic reduction gave the saturated 8-13.
36
Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents
TL;DR: In this paper, the effects of a regioisomeric change on the biological activities of previously reported water soluble, colchicine site binding, microtubule depolymerizing agents were studied.
20