61 Papers
706 Citations
Wei Hsu is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Wnt signaling pathway & Cellular differentiation. The author has an hindex of 31, co-authored 54 publications. Previous affiliations of Wei Hsu include Icahn School of Medicine at Mount Sinai & New York University.
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Papers
The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation
Li Zeng,François Fagotto,Tong Zhang,Wei Hsu,Thomas J. Vasicek,William L. Perry,James J. Lee,Shirley M. Tilghman,Barry M. Gumbiner,Frank Costantini +9 more
TL;DR: Axin is a novel inhibitor of Wnt signaling and regulates an early step in embryonic axis formation in mammals and amphibians.
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The role of Axin2 in calvarial morphogenesis and craniosynostosis
Hsiao-Man Ivy Yu,Boris Jerchow,Tzong-Jen Sheu,Bo Liu,Frank Costantini,J. Edward Puzas,Walter Birchmeier,Wei Hsu +7 more
TL;DR: The data argue for a region-specific effect of Axin2 on neural crest dependent skeletogenesis as the mammalian skull is formed from cranial skeletogenic mesenchyme, which is derived from mesoderm and neural crest, and for a novel role for the Wnt pathway in skull morphogenesis.
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Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration.
TL;DR: The findings demonstrate their true identity as skeletal stem cells with innate capacities to replace the damaged skeleton in cell-based therapy, and permit further elucidation of the stem cell-mediated craniofacial skeletogenesis, leading to revealing the complex nature of congenital disease and regenerative medicine.
227
Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.
TL;DR: It is shown that the basic leucine zipper (bZIP) region of NF-IL6 mediates a direct association with the bZIP regions of Fos and Jun in vitro, and may have a role in determining the promoter and cell type specificity in IL-6 signaling.
215
Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development.
Debbie Y Dao,Jennifer H. Jonason,Yongchun Zhang,Wei Hsu,Di Chen,Matthew J. Hilton,Regis J. O'Keefe +6 more
TL;DR: The work presented here supports the concept that the cartilage‐derived β‐catenin signal is a central mediator for major events during endochondral bone formation, including chondrocyte maturation, primary and secondary ossification center development, vascularization, and perichondrial bone formation.
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