Wei Han
Texas A&M University
9 Papers
3 Citations
Wei Han is an academic researcher from Texas A&M University. The author has contributed to research in topics: Biology & Regulation of gene expression. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Wei Han include Hospital Corporation of America & Prevention Institute.
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Papers
Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis
Shengbing Zang,Shengbing Zang,Jia Li,Jia Li,Haiyan Yang,Hongxiang Zeng,Hongxiang Zeng,Wei Han,Wei Han,Jixiang Zhang,Jixiang Zhang,Jixiang Zhang,Minjung Lee,Minjung Lee,Margie Moczygemba,Sevinj Isgandarova,Yaling Yang,Yubin Zhou,Anjana Rao,Anjana Rao,M. James You,Deqiang Sun,Deqiang Sun,Yun Huang,Yun Huang +24 more
TL;DR: It is demonstrated that TET2 loss and RhoAG17V expression in mature murine T cells cooperatively cause abnormal CD4+ T cell proliferation and differentiation by perturbing FoxO1 gene expression, phosphorylation, and subcellular localization.
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development
Shaohai Fang,Jia Li,Yang Xiao,Minjung Lee,Lei Guo,Wei Han,Tingting Li,Matthew C. Hill,TingTing Hong,William Mo,Rang Xu,Ping Zhang,Fen Wang,Jiang Chang,Yubin Zhou,Deqiang Sun,James F. Martin,Yun Huang +17 more
TL;DR: It is found that cardiac-specific deletion of Tet2 and Tet3 in mice (Tet2/3-DKO) leads to ventricular non-compaction cardiomyopathy (NCC) with embryonic lethality, and DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice are analyzed.
Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC
Jia Li,Xinwei Wu,Yubin Zhou,Minjung Lee,Lei Guo,Wei Han,William Mo,Wen-Ming Cao,Deqiang Sun,Ruiyu Xie,Yun Huang +10 more
TL;DR: It is found that 5-hydroxymethylcytosine (5hmC) marks genomic regions to be demethylated in the descendent lineage, thus reshaping the DNA methylation landscapes during pancreatic lineage progression.
Disruption of TET2 Dioxygenase Enhances Antitumor Efficiency in CD8+ Tumor Infiltrating Lymphocytes
TL;DR: The novel findings demonstrated the therapeutic potential of Tet2 inactivation in immune cells during cancer immunotherapy, and observed that Tet2 depleted CD8+ TILs displayed increased anti-tumor efficiency in a mouse model of melanoma.
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Synthetic Lethality of Combinatory Inhibition of BET and CDK7 in BET(i) Resistant Leukemia Cells
Lei Guo,Jia Li,Shaohai Fang,Minjung Lee,Hongxiang Zeng,Tingting Li,Wei Han,Deqiang Sun,Yun Huang +8 more
TL;DR: A combinatorial drug screening approach identified the synthetic lethality of BRD4 and CDK7 inhibition in BRDi resistant leukemia cells both in vitro and in vivo and identifies a new strategy that may enhance the clinical utility of BET inhibitors, especially for the treatment of BETi resistance.
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