Wei Guo
5 Papers
1 Citations
Wei Guo is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 5 publications.
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Papers
Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty
Oscar Junhong Luo,Wen Lei,Guodong Zhu,Zhiyao Ren,Yudai Xu,Chanchan Xiao,Hongyi Zhang,Junxiang Cai,Zhiping Luo,Lijuan Gao,Jun Su,Lei Tang,Wei Guo,Huanxing Su,Zhang Jin-Zhang,Evandro Fei Fang,Yijun Ruan,Sean X. Leng,Zhenyu Ju,Huiling Lou,Junling Gao,Nan Peng,Jie-fang Chen,Zhijun Bao,Feng Liu,Guobing Chen +25 more
TL;DR: In this paper , an age-dependent accumulation of transcriptome heterogeneity and variability in immune cells were identified in given cell types of specific age groups, and a frailty-specific monocyte subset was identified with exclusively high expression of long noncoding RNAs NEAT1 and MALAT1.
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First-in-human global multi-center study of RLY-2608, a pan-mutant and isoform-selective PI3Kα inhibitor, as a single agent in patients with advanced solid tumors and in combination with fulvestrant in patients with advanced breast cancer.
Cesar A. Perez,JF Henry,Andreas Varkaris,Vivek Subbiah,Alexander I. Spira,Oleg Schmidt,Jinshan Shen,Wei Guo,Tamieka Hunter,Kai Yu Jen,Mahesh Padval,Djuro Karanovic,Beni B. Wolf,Erika Hamilton +13 more
TL;DR: A first-in-human study to evaluate the clinical activity of RLY-2608 as a single agent in advanced solid tumor patients with PI3KCA mutations and in combination with fulvestrant in previously treated pts with HR+/HER2- MBC, with primary endpoints MTD/RP2D and AE profile for single agent and combination.
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753-P: RGT-075, an Orally Efficacious Small Molecule GLP-1R Full Agonist in Cynomolgus Monkey Models
TL;DR: In food-induced glucose intolerant and prediabetic cynomolgus monkeys, oral administration of RGT-075 improved glucose tolerance to a level comparable to injectable liraglutide and support the development and advancement of R GT-075 into the clinic as a potential therapeutic for T2D and obesity.
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1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages [Retraction]
Ao Duan,Zemeng Ma,Wanshun Liu,Kai Shen,Hao Zhou,Shun-Li Wang,Renyi Kong,Yuqi Shao,Yunzi Chen,Wei Guo +9 more
TL;DR: This retracts the article DOI: 10.2147/JIR.S339670 because of a lack of confidence in the authors' ability to evaluate the data.
Aortic dissection: global epidemiology
TL;DR: In this paper , the authors estimated and analyzed the incidence of aortic dissection in all 195 countries and 54 regions worldwide and in the population structures of 15 selected countries, in terms of biological, social, environmental, and psychosocial factors.