4 Papers
Wei Cui is an academic researcher from Guangzhou Institutes of Biomedicine and Health. The author has contributed to research in topics: Influenza A virus & Neuraminidase. The author has an hindex of 4, co-authored 4 publications.
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Papers
Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors
Xin Zhao,Yanling Jie,Matthew R. Rosenberg,Junting Wan,Shaogao Zeng,Wei Cui,Yiping Xiao,Zhiyuan Li,Zhengchao Tu,Marco G. Casarotto,Wenhui Hu +10 more
TL;DR: Several imidazole and guanazole derivatives of pinanamine were found to inhibit WT A/M2 to a comparable degree as amantadine and one of these compounds 12 exhibits weak inhibition of A/ M2-S31N mutant and it is marginally more effective in inhibiting S31NM2 than amantADine.
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Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus.
Jianghong Dong,Shengwei Chen,Runfeng Li,Wei Cui,Haiming Jiang,Yixia Ling,Zifeng Yang,Wenhui Hu +7 more
TL;DR: In this article, a structure-activity relationship study of a series of imidazole-linked pinanamine derivatives was conducted by modifying the imidaze ring of this compound, which was identified as being active on an amantadine-sensitive virus through blocking of the viral M2 ion channel.
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Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses
Xin Zhao,Xin Zhao,Xin Zhao,Runfeng Li,Yang Zhou,Mengjie Xiao,Mengjie Xiao,Chunlong Ma,Zhongjin Yang,Shaogao Zeng,Qiuling Du,Chunguang Yang,Haiming Jiang,Yanmei Hu,Kefeng Wang,Chris Ka Pun Mok,Chris Ka Pun Mok,Ping Sun,Jianghong Dong,Wei Cui,Jun Wang,Yaoquan Tu,Zifeng Yang,Wenhui Hu,Wenhui Hu +24 more
TL;DR: A structure-activity relationship (SAR) of pinanamine-based antivirals is explored and a potent inhibitor M090 is discovered against amantadine-resistant viruses, including the 2009 H1N1 pandemic strains, and oseltamivir- resistant viruses.
Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus
Xin Zhao,Zhen-Wei Zhang,Wei Cui,Shengwei Chen,Yang Zhou,Jianghong Dong,Yanling Jie,Junting Wan,Yong Xu,Wenhui Hu +9 more
TL;DR: The molecular docking revealed that compound 18 occupies more space in the M2 ion channel than amantadine and thus exhibits enhanced activity and was found to be more potent than amanadine against wild-type influenza virus.