39 Papers
642 Citations
Wei Chao is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Virus & Gene. The author has an hindex of 25, co-authored 39 publications. Previous affiliations of Wei Chao include Columbia University & Mount Sinai St. Luke's and Mount Sinai Roosevelt.
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Papers
Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH.
Zao-Zhong Su,Dong-Chul Kang,Yinming Chen,Olga Pekarskaya,Wei Chao,David J. Volsky,David J. Volsky,Paul B. Fisher +7 more
TL;DR: The comparable pattern of regulation of the AEGs following HIV-1 infection or gp120 treatment suggest that HIV- 1 exposure of astrocytes, even in the absence of productive infection, can induce changes in cellular gene expression.
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Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120.
Zhuying Wang,Olga Pekarskaya,Meryem Bencheikh,Wei Chao,Harris A. Gelbard,Anuja Ghorpade,Jeffrey D. Rothstein,David J. Volsky +7 more
TL;DR: It is demonstrated that HIV-1 and gp120 induce transcriptional downmodulation of the EAAT2 transporter gene in human astrocytes and coordinately attenuate glutamate transport by the cells to contribute to the development of neurological disease.
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Insights into glutamate transport regulation in human astrocytes: Cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)
Zao-Zhong Su,Magdalena Leszczyniecka,Dong-Chul Kang,Devanand Sarkar,Wei Chao,D. J. Volsky,Paul B. Fisher +6 more
TL;DR: It is raised the intriguing possibility that the EAAT2 promoter may be useful for targeting gene expression in the brain and for identifying molecules capable of modulating glutamate transport that could potentially inhibit, ameliorate, or prevent various neurodegenerative diseases.
206
Detection of HIV-1 DNA in Microglia/ Macrophages, Astrocytes and Neurons Isolated from Brain Tissue with HIV-1 Encephalitis by Laser Capture Microdissection
Gusta Trillo-Pazos,A Diamanturos,L. Rislove,Timothy W Menza,Wei Chao,P. Belem,S. Sadiq,Susan Morgello,Leroy R. Sharer,David J. Volsky +9 more
TL;DR: HIV‐1 gag DNA was consistently detected in the frontal cortex and basal ganglia in 1 to 20 p24 HIV‐1 capsid positive cells, and in pools of 50 to 100 microglia/macrophage cells,100 to 200 astrocytes, and 100 to 200 neurons in HIV-1 positive cases but not in HIV‐ 1 negative controls.
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A mouse model for study of systemic HIV-1 infection, antiviral immune responses, and neuroinvasiveness
Mary Jane Potash,Wei Chao,Galina Bentsman,Nicolae Paris,Manisha Saini,Jadwiga Nitkiewicz,Paula Belem,Leroy R. Sharer,Andrew Brooks,David J. Volsky +9 more
TL;DR: EcoHIV infection of mice forms a useful model of HIV-1 infection of human beings for convenient and safe investigation of HIV -1 therapy, vaccines, and potentially pathogenesis.
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