Wei An
7 Papers
Wei An is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation
Shelly C. Lu,Luis W. Alvarez,Zong-Zhi Huang,Lixin Chen,Wei An,Fernando J. Corrales,Matías A. Avila,Gary Kanel,José M. Mato +8 more
TL;DR: In this paper, the effects of a targeted disruption of the murine MAT1A gene on hepatic growth were examined in homozygous mice, and the results showed that the absence of MAT1a resulted in a liver that is more susceptible to injury, expresses markers of an acute phase response, and displays increased proliferation.
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Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
TL;DR: This study shows that Smurf1 is involved in the pathogenesis of NAFLD by balancing de novo lipid synthesis and lipolysis by interacting with and stabilizing mouse double minute 2 (MDM2) and promoting p53 degradation.
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Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma
TL;DR: In this article , the authors focused on ALR ubiquitination-mediated degradation and its potential contribution to NASH-driven HCC progression at the mitochondrial level, and showed that liver-specific deletion of ALR (ALRCKO) and ALRWT mice were fed a western diet (WD) and high-sugar solution for induction of NASH.
[Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].
L. Li,Peng Xie,Chun-Shan Bi,T. Y. Wang,N. Wang,W. W. Lin,Ce Zhang,Wei An,Yu-Tao Zhan +8 more
- 01 Jan 2023
TL;DR: In this paper , the effect and underlying mechanism of casein kinase 2 interacting protein-1 (CKIP-1) on hepatocyte apoptosis in nonalcoholic fatty liver disease (NAFLD) was explored.
Cbl and Cbl-b Ubiquitin Ligases are Essential for Intestinal Epithelial Stem Cell Maintenance
Neha Zutshi,Bhopal Mohapatra,P. Mondal,Wei An,Benjamin T. Goetz,Sicong Li,Matthew D. Storck,David W. Mercer,Adrian R. Black,Sarah P. Thayer,Jennifer D. Black,Vimla Band,Hamid Band +12 more
TL;DR: In this paper , the authors examined the impact of inducible Cbl/Cblb double-KO (iDKO) selectively in the Lgr5-defined intestinal stem cell (ISC) compartment.