The need for new antibacterial drugs to treat the increasing global prevalence of drug-resistant bacterial infections has clearly attracted global attention, with a range of existing and upcoming funding, policy, and legislative initiatives designed to revive antibacterial R&D. It is essential to assess whether these programs are having any real-world impact and this review continues our systematic analyses that began in 2011. Direct-acting antibacterials (47), non-traditional small molecule antibacterials (5), and β-lactam/β-lactamase inhibitor combinations (10) under clinical development as of December 2022 are described, as are the three antibacterial drugs launched since 2020. Encouragingly, the increased number of early-stage clinical candidates observed in the 2019 review increased in 2022, although the number of first-time drug approvals from 2020 to 2022 was disappointingly low. It will be critical to monitor how many Phase-I and -II candidates move into Phase-III and beyond in the next few years. There was also an enhanced presence of novel antibacterial pharmacophores in early-stage trials, and at least 18 of the 26 phase-I candidates were targeted to treat Gram-negative bacteria infections. Despite the promising early-stage antibacterial pipeline, it is essential to maintain funding for antibacterial R&D and to ensure that plans to address late-stage pipeline issues succeed. 

/pdf/antibiotics-in-the-clinical-pipeline-as-of-december-2022-16jjeayo.pdf

Antibiotics in the clinical pipeline as of December 2022

The Eschenmoser sulfide contraction method and its application in the synthesis of natural products

Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria

Development of a Practical and Convergent Process for the Preparation of Sulopenem

Synthesis and Reactivity of α-Haloglycine Esters: Hyperconjugation in Action.

Development of a Second-Generation Process to Antibacterial Candidate Sulopenem

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Development of a Second-Generation Process to Antibacterial Candidate Sulopenem