Wayne P. Bocchinfuso
National Institutes of Health
10 Papers
209 Citations
Wayne P. Bocchinfuso is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 10, co-authored 10 publications.
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Papers
Mammary gland development and tumorigenesis in estrogen receptor knockout mice.
TL;DR: The generation of the ER knockout (ERKO) mouse has made it possible to directly understand the contribution of ER in mammary development and has provided an unique opportunity to study estrogen action in carcinogenesis, providing the impetus to evaluate the effect of other oncogenes in Mammary tumorigenesis in the absence of estrogen/ER signaling.
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Induction of Mammary Gland Development in Estrogen Receptor-α Knockout Mice
Wayne P. Bocchinfuso,Jonathan Lindzey,Sylvia C. Hewitt,James A. Clark,Page Myers,Ralph L. Cooper,Kenneth S. Korach +6 more
TL;DR: The manifestation of the alphaERKO mammary phenotype appears due to the lack of direct estrogen action at the mammary gland and an indirect contributory role of estrogen signaling at the hypothalamic/pituitary axis.
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Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms
Wei Yue,Ji-Ping Wang,Yuebai Li,Ping Fan,Guijian Liu,Nan Zhang,Mark R. Conaway,Hongkun Wang,Kenneth S. Korach,Wayne P. Bocchinfuso,Richard J. Santen +10 more
TL;DR: The results suggest that ER‐independent actions of E2 can influence breast tumor development in concert with ER dependent effects, and suggest 1 mechanism whereby AIs, which block E2 synthesis, would be more effective for breast cancer prevention than use of antiestrogens, which only block ER‐mediated effects.
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•Journal Article
A Mouse Mammary Tumor Virus-Wnt-1 Transgene Induces Mammary Gland Hyperplasia and Tumorigenesis in Mice Lacking Estrogen Receptor-α
TL;DR: It is concluded that ectopic expression of the Wnt-1 proto-oncogene can induce mammary hyperplasia and tumorigenesis in the absence of ERα in female and male mice.
147
Potency of combined estrogenic pesticides.
Kavita Ramamoorthy,Fen Wang,Ichen Chen,Stephen Safe,John D. Norris,Donald P. McDonnell,Kevin W. Gaido,Wayne P. Bocchinfuso,Kenneth S. Korach,John A. McLachlan,Steven F. Arnold,Diane M. Klotz,Bridgette M. Collins,Peter M. Vonier,Louis J. Guillette +14 more
TL;DR: Brain hemispheres fixed in buffered 10% formalin were fixed overnight with a solution of 1% glutaraldehyde and 1% paraformaldehyde in 0.12 M phosphate buffer to develop any neurological disease.
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