Wayne Chang
Boston University
7 Papers
8 Citations
Wayne Chang is an academic researcher from Boston University. The author has contributed to research in topics: Working memory & Synapse. The author has an hindex of 3, co-authored 7 publications.
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Papers
Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease.
Joseph W. Goodliffe,Hanbing Song,Anastasia Rubakovic,Wayne Chang,Maria Medalla,Christina M. Weaver,Jennifer I. Luebke +6 more
TL;DR: Examination of 12-month-old Q175+/- x D2-eGFP mice reveals that, by twelve months, D1 and D2 MSNs exhibit distinctive responses to the presence of mHTT in this important mouse model of HD, which further highlights the need to incorporate findings from D0 and D1 MSNs independently in the context of HD models.
Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys.
TL;DR: Modeling pyramidal neuron hyperexcitability and synapse loss simultaneously led to a partial recovery of function in both tasks, with the simulated level of DRSTsp impairment similar to that observed in aging monkeys.
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Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.
TL;DR: The authors found that the appropriate time frame for intervention for age-related cognitive changes is early middle age, and points to the efficacy of curcumin in delaying WM decline in rhesus monkeys.
2
Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks.
Maria Medalla,Wayne Chang,S. Ibáñez,Teresa Guillamon-Vivancos,Teresa Guillamon-Vivancos,Mathias Nittmann,Mathias Nittmann,Anastasia Kapitonava,Silas E. Busch,Silas E. Busch,Tara L. Moore,Douglas L. Rosene,Jennifer I. Luebke +12 more
TL;DR: In this article, the authors used multimodal tract-tracing, in vitro patch-clamp recording and computational approaches in rhesus monkeys (M. mulatta) to provide evidence that specialized motor and affective network dynamics can be conferred by layer-specific biophysical and structural properties of ACC pyramidal neurons targeting two key downstream structures.
Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex.
Maria Medalla,Wayne Chang,Samantha M. Calderazzo,Veronica Go,Alexandra Tsolias,Joseph W. Goodliffe,Dhruba Pathak,Diego De Alba,Monica A. Pessina,Douglas L. Rosene,Benjamin Buller,Tara L. Moore +11 more
TL;DR: These data show that EV treatment dampens injury-related hyperexcitability and restores excitatory:inhibitory balance in vPMC, thereby normalizing activity within cortical networks for motor function.