Warren Thomas
Royal College of Surgeons in Ireland
70 Papers
374 Citations
Warren Thomas is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Aldosterone & Mineralocorticoid receptor. The author has an hindex of 24, co-authored 62 publications. Previous affiliations of Warren Thomas include Newbury College & King's College London.
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Papers
How bacteria could cause cancer: one step at a time
Alistair J. Lax,Warren Thomas +1 more
TL;DR: Chronic infection with other bacteria, notably Salmonella typhi, can also facilitate tumour development, and several bacterial toxins interfere with cellular signalling mechanisms in a way that is characteristic of tumour promoters.
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Non-genomic actions of aldosterone: from receptors and signals to membrane targets.
TL;DR: In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocortICoid-regulated kinase-1.
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Lavender essential oil induces oxidative stress which modifies the bacterial membrane permeability of carbapenemase producing Klebsiella pneumoniae.
Shun-Kai Yang,Khatijah Yusoff,Warren Thomas,Riaz Akseer,Maryam Sultan Alhosani,Aisha Abushelaibi,Swee-Hua-Erin Lim,Swee-Hua-Erin Lim,Kok-Song Lai +8 more
TL;DR: The data suggest that LVO induced oxidative stress in K. pneumoniae which oxidizes the outer membrane, enabling the influx of generated ROS, LVO and meropenem into the bacterial cells, causing damage to the cells and eventually death.
Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR
Chew-Li Moo,Shun-Kai Yang,Khatijah Yusoff,Mokrish Ajat,Warren Thomas,Aisha Abushelaibi,Swee-Hua-Erin Lim,Kok-Song Lai +7 more
TL;DR: This review will briefly detail the causes and mechanisms of AMR, and provide insights into novel, future emerging or evolving strategies that are currently being evaluated and which may be developed in the future to tackle the progression ofAMR.
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Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation.
Raphael Rapetti-Mauss,Viviana Bustos,Warren Thomas,Jean McBryan,Harry Harvey,Natalia Lajczak,Stephen F. Madden,Bernard Pellissier,Franck Borgese,Olivier Soriani,Brian J. Harvey +10 more
TL;DR: It is concluded that the KCNQ1 ion channel is a target gene and regulator of the Wnt/β-catenin pathway, and its repression leads to CRC cell proliferation, EMT, and tumorigenesis.
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