Warner C. Greene
University of California, San Francisco
435 Papers
9.7K Citations
Warner C. Greene is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Receptor. The author has an hindex of 116, co-authored 421 publications. Previous affiliations of Warner C. Greene include Toronto General Hospital & Hoffmann-La Roche.
Chat about Author
Papers
Duration of nuclear NF-κB action regulated by reversible acetylation
TL;DR: It is demonstrated that the RelA subunit of NF-κB is subject to inducible acetylation and that acetylated forms of RelA interact weakly, if at all, with IκBα.
Shaping the nuclear action of NF-κB
Lin Feng Chen,Warner C. Greene +1 more
TL;DR: The NF-κB/REL family of transcription factors pivotally control the inflammatory and immune responses, as well as other genetic programmes that are central to cell growth and survival.
1.2K
NF-κB controls expression of inhibitor IκBα : evidence for an inducible autoregulatory pathway
TL;DR: Transfection studies indicate that the I kappa B alpha gene is specifically induced by the 65-kilodalton transactivating subunit of NF-kappa B, and association of the newly synthesized I k Kappa B alpha with p65 restores intracellular inhibition of NF -kappaB DNA binding activity and prolongs the survival of this labile inhibitor.
1.1K
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
Gilad Doitsh,Nicole L. K. Galloway,Xin Geng,Zhiyuan Yang,Kathryn M. Monroe,Orlando Zepeda,Peter W. Hunt,Hiroyu Hatano,Stefanie Sowinski,Isa Muñoz-Arias,Warner C. Greene +10 more
TL;DR: It is shown that caspase-3-mediated apoptosis accounts for the death of only a small fraction of CD4 T cells corresponding to those that are both activated and productively infected, which links the two signature events in HIV infection—CD4 T-cell depletion and chronic inflammation—and creates a pathogenic vicious cycle.
1.1K
The challenge of finding a cure for HIV infection.
Douglas D. Richman,David M. Margolis,Martin Delaney,Warner C. Greene,Daria J. Hazuda,Roger J. Pomerantz +5 more
TL;DR: The current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure are discussed.