Wanwan Shen
East China Normal University
13 Papers
11 Citations
Wanwan Shen is an academic researcher from East China Normal University. The author has contributed to research in topics: Gene delivery & Nanoparticle. The author has an hindex of 10, co-authored 13 publications.
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Papers
The fluorination effect of fluoroamphiphiles in cytosolic protein delivery.
TL;DR: A type of polymers, fluoroamphiphiles, acting as chemical chaperones that can facilitate the import of proteins into the inner compartment, i.e. cytosol, of cells are presented.
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Natural Polyphenols Augment Cytosolic Protein Delivery by a Functional Polymer
TL;DR: This study proposed a novel strategy to deliver proteins of different molecular sizes and isoelectric points by specific recognitions between natural polyphenols and boronic acid-containing polymers.
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Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy of Bladder Cancer.
Guangzhi Li,Qifang Lei,Fei Wang,Dashi Deng,Shupeng Wang,Longlong Tian,Wanwan Shen,Yiyun Cheng,Zhuang Liu,Song Wu +9 more
TL;DR: Aiming at improved intravesical instillation therapy of bladder cancer, a fluorinated polyethylenimine (F-PEI) is employed here for the transmucosal delivery of an active venom peptide, polybia-mastoparan I (MPI), which shows selective antiproliferative effect against various bladder cancer cell lines.
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Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery
Wanwan Shen,Ruojun Wang,Qianqian Fan,Xiao Gao,Hui Wang,Yang Shen,Yiwen Li,Yiyun Cheng,Yiyun Cheng +8 more
- 01 Jun 2020
TL;DR: There is a continuing quest to rationally fabricate polymeric biomaterials with both high transfection efficiency and minimal toxicity for the emerging opportunities in small interfering RNA (siRNA) research.
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Screening of efficient polymers for siRNA delivery in a library of hydrophobically modified polyethyleneimines.
TL;DR: The revealed structure-activity relationships of alkylated, cycloalksylated and fluoroalkylated PEIs in this study provide a new insight into the design of highly efficient and non-toxic siRNA carriers.
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