Wangzhi Li
Cold Spring Harbor Laboratory
7 Papers
Wangzhi Li is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Biology & Chromodomain. The author has an hindex of 5, co-authored 5 publications.
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Papers
TAp63 induces senescence and suppresses tumorigenesis in vivo
Xuecui Guo,William M. Keyes,Cristian Papazoglu,Cristian Papazoglu,Johannes Zuber,Wangzhi Li,Scott W. Lowe,Scott W. Lowe,Hannes Vogel,Alea A. Mills +9 more
TL;DR: It is demonstrated that TAp63 isoforms function as tumour suppressors by regulating senescence through p53-independent pathways, and is identified as a potential target of anti-cancer therapy for human malignancies with compromised p53.
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ΔNp63α Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis
William M. Keyes,Matteo Pecoraro,Victoria Aranda,Emma Vernersson-Lindahl,Wangzhi Li,Hannes Vogel,Xuecui Guo,Elvin L. Garcia,Tatyana V. Michurina,Grigori Enikolopov,Senthil K. Muthuswamy,Senthil K. Muthuswamy,Alea A. Mills +12 more
TL;DR: It is indicated that ΔNp63α is an oncogene that cooperates with Ras to promote tumor-initiating stem-like proliferation and suggest that Lsh-mediated chromatin-remodeling events are critical to this process.
197
Chd5 orchestrates chromatin remodelling during sperm development.
Wangzhi Li,Jie Wu,Sang Yong Kim,Ming Zhao,Stephen Hearn,Michael Q. Zhang,Marvin L. Meistrich,Alea A. Mills +7 more
TL;DR: These findings define Chd5 as a multi-faceted mediator of histone-to-protamine replacement and depict the cascade of molecular events underlying this process of extensive chromatin remodelling.
Packing for the journey: CHD5 remodels the genome
Wangzhi Li,Alea A. Mills +1 more
TL;DR: Sperm are highly specialized cells charged with the sole responsibility of delivering the paternal genome to offspring, so the genome is protected from the harsh environment that the sperm encounters during its epic journey from the safety of the testes, through the female reproductive tract, to its ultimate destination, the receptive oocyte.
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Syringic acid (SA) inhibits the IL-1β-induced inflammation in mice chondrocytes and ameliorates the progression of osteoarthritis via the PTEN/AKT/NF-κB pathway
TL;DR: Syringic acid (SA) inhibits IL-1β-induced inflammation in mice chondrocytes and ameliorates osteoarthritis progression via the PTEN/AKT/NF-κB pathway, suggesting its potential as a treatment candidate for osteoarthritis.
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