Wang Muxuan
Shandong Normal University
5 Papers
Wang Muxuan is an academic researcher from Shandong Normal University. The author has contributed to research in topics: A549 cell & HeLa. The author has an hindex of 2, co-authored 5 publications.
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Papers
Design, synthesis and bioactive evaluation of geniposide derivatives for antihyperuricemic and nephroprotective effects.
Wang Muxuan,Chen Jiashu,Zhang Ruirui,Xinyan Guo,Daxia Chen,Guo Xu,Yingying Chen,Yuhao Wu,Jin-yue Sun,Yu-fa Liu,Chao Liu +10 more
TL;DR: In this article, a series of geniposide derivatives were designed and synthesized, and antihyperuricemic and nephroprotective effects of all derivatives was evaluated in vitro and in vivo.
17
Design, synthesis and in vitro evaluation of fangchinoline derivatives as potential anticancer agents
TL;DR: The results suggested that compound 3i induces apoptosis through a mitochondria-mediated intrinsic pathway and is a promising candidate for future development as an anti-tumor drug.
12
Design, synthesis and in vitro anticancer research of novel tetrandrine and fangchinoline derivatives.
Xiu-zheng Gao,Xu-tao Lv,Zhang Ruirui,Yang Luo,Wang Muxuan,Chen Jiashu,Yu-kai Zhang,Sun Bin,Jin-yue Sun,Yu-fa Liu,Chao Liu +10 more
TL;DR: In this paper, twenty new Tet and d-Tet derivatives were designed, synthesized and evaluated as antitumor agents against six cancer cell lines (H460, H520, HeLa, HepG-2, MCF-7, SW480 cell lines) and BEAS-2B normal cells by CCK-8 analysis.
10
Two new diterpenoids with their antiproliferative activities from the supercritical fluid extraction of Croton crassifolius root
Chao Liu,Zhang Ruirui,Qing-lin Niu,Jing Zhang,Wang Muxuan,Na-na Meng,Wang Qing,Jin-Yue Sun,Wen-Liang Wang +8 more
TL;DR: In vitro anti-proliferative activities of compounds 1 and 2 on A549, Hep-G2 and Hela tumor cell lines were evaluated, and the two new compounds exhibited obvious selectivity to tumor cells with IC50 values ranging from 20.43 ± 1.18 μM to 25.72±1.32M.
8
PDB-1 from Potentilla discolor Bunge induces apoptosis and autophagy by downregulating the PI3K/Akt/mTOR signaling pathway in A549 cells.
Zhang Ruirui,Na-na Meng,Chao Liu,Kui-lin Li,Wang Muxuan,Zhi-bo Lv,Shu-ya Chen,Guo Xu,Wang Xinkun,Wang Qing,Jin-yue Sun +10 more
TL;DR: Results indicated that PDB-1 may be considered a potential candidate for the future treatment of lung adenocarcinoma and should benefit the development of the C14-COOH type of pentacyclic triterpenoids.