5 Papers
26 Citations
Wang M is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: DHTKD1 & Enzyme. The author has an hindex of 3, co-authored 5 publications.
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Papers
Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex
João Leandro,Susmita Khamrui,Hui Wang,Chalada Suebsuwong,Natalia S. Nemeria,Khoi Huynh,Moses Moustakim,Cody Secor,Wang M,Tetyana Dodatko,Brandon Stauffer,Christopher G. Wilson,Chunli Yu,Chunli Yu,Michelle R. Arkin,Frank Jordan,Roberto Sanchez,Robert J. DeVita,Michael B. Lazarus,Sander M. Houten +19 more
TL;DR: The identification of adipoylphosphonic acid and tenatoprazole as DHTKD1 inhibitors using targeted and high throughput screening, respectively, and the crystal structure of the E1 component of the 2-oxoadipate dehydrogenase complex is elucidated, providing chemical and structural tools for further understanding of the function of DHTD1 and its role in several human pathologies.
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Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex
João Leandro,Susmita Khamrui,Hui Wang,Chalada Suebsuwong,Natalia S. Nemeria,Khoi Huynh,Moses Moustakim,Cody Secor,Wang M,Tetyana Dodatko,Brandon Stauffer,Christopher G. Wilson,Chunli Yu,Chunli Yu,Michelle R. Arkin,Frank Jordan,Roberto Sanchez,Robert J. DeVita,Michael B. Lazarus,Sander M. Houten +19 more
TL;DR: This work provides a structural basis for further understanding of the function of DHTKD1 and a starting point for selective small molecule inhibitors of the enzyme, which could help tease apart the role of this enzyme in several human pathologies.
Molecular Networks and Key Regulators of the Dysregulated Neuronal System in Alzheimer’s Disease
Wang M,Li A,Michiko Sekiya,Noam D. Beckmann,Quan X,Nadine Schrode,Michael B. Fernando,Yu A,Lin Zhu,Lin Zhu,Jiqing Cao,Jiqing Cao,Lyu L,Emrin Horgusluoglu,Qing Jun Wang,Lei Guo,Ying-Chih Wang,Ryan Neff,Won-Min Song,Erming Wang,Qi Shen,Xianxiao Zhou,Chen Ming,Seok-Man Ho,Sezen Vatansever,H. U. Kaniskan,Jian Jin,Ming-Ming Zhou,Kanae Ando,Lap Ho,Paul A. Slesinger,Zhenyu Yue,Jun Zhu,Sam Gandy,Michelle E. Ehrlich,Dongming Cai,Dongming Cai,Haroutunian,Koichi M. Iijima,Eric E. Schadt,Kristen J. Brennand,Bin Zhang +41 more
TL;DR: This study advances the understanding of LOAD pathogenesis by providing the global landscape and detailed circuits of complex molecular interactions and regulations in several key brain regions affected by LOAD and the resulting network models provide a blueprint for developing next generation therapeutics against LOAD.
Functional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models
Ying-Wooi Wan,Rami Al-Ouran,Carl Grant Mangleburg,Tom V. Lee,Tom V. Lee,Katherine Allison,Katherine Allison,Sarah M. Neuner,Catherine C. Kaczorowski,Phillip,Phillip,Gareth R. Howell,Heidi Martini-Stoica,Hui Zheng,Jungwoo Wren Kim,Jungwoo Wren Kim,Dawson,Ted M. Dawson,Ping-Chieh Pao,Ping-Chieh Pao,Li-Huei Tsai,Li-Huei Tsai,Jean-Vianney Haure-Mirande,Wang M,Michelle E. Ehrlich,Hongkang Mei,Xiaoyan Zhong,Paramita Chakrabarty,Yona Levites,Todd E. Golde,Levey Ai,Ben Logsdon,Lara M. Mangravite,Zhandong Liu,Zhandong Liu,Joshua M. Shulman,Joshua M. Shulman +36 more
TL;DR: An attempt is made to evaluate the role of EMT in the development of Huntington’s disease in relation to brain gene expression in humans and mice.
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Multiscale causal network models of Alzheimer’s disease identify VGF as a key regulator of disease
Noam D. Beckmann,Wei-Jye Lin,Wang M,Ariella Cohain,Pei Wang,Weiping Ma,Ying-Chih Wang,Jiang C,Mickael Audrain,Phillip H. Comella,Siddharth P. Hariharan,Gillian M. Belbin,Levey Ai,Nicholas T. Seyfried,Eric B. Dammer,Duc M. Duong,Lah Jj,Jean-Vianney Haure-Mirande,Shackleton B,Alexander W. Charney,Eimear E. Kenny,Jun Zhu,Haroutunian,Pavel Katsel,Sam Gandy,Tu Z,Michelle E. Ehrlich,Bin Zhang,Salton,Eric E. Schadt +29 more
TL;DR: A causal and/or protective role for VGF in AD pathogenesis and progression is supported, with significant enrichment for homologous genes identified as differentially expressed in 5xFAD brains overexpressing VGF versus controls.