The invention discloses a piezoelectric ceramic driving based digital hydraulic pump. A pump body is divided into an upper portion and a lower portion by an elastic membrane, the upper portion is an oilway structure, and the lower portion is a driving structure. The oilway structure comprises an oil inlet and an oil outlet, the oil inlet is communicated with a pump cavity above the elastic membrane through an oil inlet one-way valve, and the pump cavity is communicated with the oil outlet through an oil outlet one-way valve. The driving structure comprises a piezoelectric stack actuator, a rigid component and a spring, the spring sleeves a push rod of the piezoelectric stack actuator, the rigid component is arranged at the top end of the push rod and is fixedly connected with the elastic membrane, and the piezoelectric stack actuator, the oil inlet one-way valve and the oil outlet one-way valve are controlled by a controller. The piezoelectric stack actuator high in push force and large in displacement is used as a driving source, and the maximum rated operation pressure can reach 10Mpa. By adopting the controller to control the number of layers involved in driving in the piezoelectric stack actuator, pumping flow is digitally controlled.

Piezoelectric ceramic driving based digital hydraulic pump

The invention provides an intelligent gear-shifting top-spray shower head, belongs to the technical field of shower equipment and solves the problems that a conventional top-spray shower head cannot realize automatic gear shifting and is high in cost. The intelligent gear-shifting top-spray shower head comprises a housing with a water inlet formed in the upper side, wherein a plurality of groups of water outlet holes are formed in the bottom of the housing, and mutually independent water outlet cavities of which the number is equal to that of the groups of water outlet holes are formed in the housing; the water outlet cavities are communicated with the groups of water outlet holes in a one-to-one correspondence manner; a leading structure with both a water inlet end and a plurality of water outlet ends, a driving part capable of driving the leading structure, an inductor and a power supply unit capable of powering up the driving part are fixed in the housing; the water inlet end of the leading structure is communicated with the water inlet of the housing, the number of the water outlet ends is equal to that of the water outlet cavities, and the water outlet ends and the water outlet cavities are communicated in a one-to-one correspondence manner; the driving part can drive the leading structure to switch according to an induction signal of the inductor to be optionally communicated with one or more of the water outlet ends. The intelligent gear-shifting top-spray shower head has the advantages of being automatic in control, convenient to use, low in cost and the like.

Intelligent gear-shifting top-spray shower head

The invention discloses a multi-color multi-parameter portable flow cytometer, relates to the field of life and medical science, and solves the problems that a conventional flow cytometer is large in size, high in cost, little in type of excitation light sources and small in number of detection channels. The multi-color multi-parameter portable flow cytometer comprises an LED light source group, a light source shaping system, a flowing chamber, a liquid flow driving system, a forward path signal acquisition system, a lateral path signal acquisition system and a data analysis system, wherein the LED light source group is used for emitting multiple rays with different wavelengths; the rays are shaped by the light source shaping system to emit rectangular light spots; an object to be detected is conveyed into the flowing chamber through the liquid flow driving system and passes through fluid channels in sequence to reach a laser detection area; the object to be detected is radiated by the rectangular light spots to excite scattered light and fluorescent light of different wave bands; the forward path signal acquisition system is used for converting a scattered light signal into an electric signal; the lateral path signal acquisition system is used for converting scattered light signals and fluorescent light signals into electric signals; the data analysis system is used for receiving the electric signals and outputting an analysis result. The multi-color multi-parameter portable flow cytometer is small in size and convenient to carry and has multiple excitation light sources and multiple detection channels.

Multi-color multi-parameter portable flow cytometer

The invention discloses a flow cytometry analysis device and method. The analysis device comprises a loading detection device, a sheath fluid device and a pressure supply device, wherein the loading detection device comprises a sample container, a loading pipeline, a flow detector and a flow chamber; the sample container is used for containing a sample solution and is sealed by virtue of a sealing piece; one end of the loading pipeline is connected with the sample container, the flow detector is arranged on the loading pipeline, and the flow chamber is connected with the other end of the loading pipeline; the sheath fluid device comprises a sheath fluid container, a sheath fluid pipeline and a first valve device; one end of the sheath fluid pipeline is connected with the sheath fluid container; the first valve device is arranged on the sheath fluid pipeline; the pressure supply device comprises an air source, a first air pressure pipeline and a second air pressure pipeline; the first air pressure pipeline is connected between the air source and the sample container; and the second air pressure pipeline is connected between the air source and the sheath fluid container. According to the flow cytometry analysis device provided by the invention, the problem of low analysis accuracy is solved on the basis of low cost and convenience in use.

Flow cytometry analysis device and method

The invention discloses a miniature flow cytometer fluid path system. The system comprises a flowing chamber, a sample pipeline, a sheath fluid pipeline, a waste fluid pipeline and a gas pipeline. A sample to be tested is conveyed via a small-flow peristaltic pump and then flows into the flowing chamber after passing through a pulse buffer; sheath fluid is conveyed via a large-flow peristaltic pump or a diaphragm pump and then unilaterally or symmetrically flows into the flowing chamber after passing through a bag type filter element and the pulse buffer; a miniature air pump is connected to the flowing chamber via an one-way valve so as to remove pipeline bubbles. A pressure sensor is mounted at the exit of the flowing chamber and is used for monitoring pressure change and abnormity. A liquid level sensor is arranged in each of a sheath fluid pool and a waste fluid pool and is used for setting a liquid level alarm. A filter screen is mounted at the atmospheric connection part of the sheath fluid pool and the miniature air pump to prevent impurities from entering. Through the omission of an air pressure pump in a traditional miniature flow cytometer, the miniature flow cytometer fluid path system is simple in structure and convenient to clean, has the function of removing bubbles and can meet the application requirement on miniaturization of the miniature flow cytometer.

Miniature flow cytometer fluid path system

The invention discloses a microfluidic chip system for screening rare cells. The system comprises a microfluidic chip, an optical signal excitation and detection module, a data acquisition analysis and control module, a piezoelectric driving module and a pump control module. A piezoelectric element is adopted to excite a surface wave sound field, part of non-target substances can be removed by coarse screening on the basis of physical properties of cells, and the purity and the capture rate of fine screening can be improved; meanwhile, effects of cleaning and three-dimensional focusing on a sample can be realized, and the accuracy of subsequent detection and fine screening is improved; the piezoelectric element is used for exciting a surface acoustic wave in a fine screening area, so that the target cells in fluid are driven to deviate from an original path, cell sorting can be realized quickly, and activity of the cells is not affected due to mechanical force acting on the cells. The system has no damage to the cells, can be used for conventional flow cell sorting and rare cell screening, and has great significance in promoting non-invasive prenatal screening and tumor prognosis detection.

Microfluidic chip system for screening rare cells

The invention discloses a piezoelectric ceramic diaphragm pump, which comprises an elastic film, a spherical shell, a vibrating tube, a piezoelectric element, a pump cavity roof cover, a sealing gasket, a pump cavity bottom cover, an inlet check valve, an outlet check valve and a diaphragm. The outer wall of one end of the vibrating tube is connected with the piezoelectric element; the end face of the other end of the vibrating tube is connected with the spherical shell; the opening of the spherical shell is sealed by the elastic film; the common end of the piezoelectric element and the vibrating tube is fixedly connected with the pump cavity roof cover; the diaphragm is arranged in the pump cavity roof cover; the pump cavity roof cover is fixedly connected with the sealing gasket and the pump cavity bottom cover; the pump cavity bottom cover is provided with the inlet check valve and the outlet check valve. By adopting the technical scheme provided by the invention, the piezoelectric ceramic diaphragm pump has the characteristics of simple structure, convenient control, high output efficiency and high-frequency drive, and also can achieve the goals of no pollution, corrosion resistance and high single flow rate of pumping solution. Moreover, the piezoelectric ceramic diaphragm pump has the characteristic that quantitative input liquid can be kept.

Piezoelectric ceramic diaphragm pump

The utility model discloses a micro-fluidic chip for screening rare cells in whole blood. The micro-fluidic chip comprises a micro-pipeline and a platelet removal region which is formed on the micro-pipeline through a first interdigital electrode group in sequence, wherein the red blood cell lysis region is formed through a lysis pipeline section on the micro-pipeline, the red blood cell removal region is formed on the micro-pipeline through a second interdigital electrode group, the white blood cell removal region is formed on the micro-pipeline through a magnetic field, and the target cell extraction region is formed on the micro-pipeline through a third interdigital electrode group. According to the utility model, blood platelets and cracked red blood cells are removed by utilizing thesize difference, and white blood cells are removed by utilizing a specific monoclonal antibody and magnetic beads, so that the purity and capture rate of target cell screening are improved; meanwhile,a sample can be cleaned. The system disclosed by the utility model has no damage to cells, can be used for conventional flow cytometry sorting, can also be used for screening rare cells, and has veryimportant significance for promoting non-invasive prenatal screening and tumor prognosis detection.

Micro-fluidic chip for screening rare cells in whole blood

The invention discloses a water quality detection method and system. The water quality detection method comprises the following steps: mixing sample water to be detected with a fluorescent dye to obtain dyed sample water to be detected, wherein the fluorescent dye is a reagent which generates fluorescence under excitation of a preset-wavelength laser; performing laser radiation on the dyed samplewater to be detected via an optical signal detection device to obtain scattered light intensity and/or fluorescence intensity; and acquiring a detection result of the sample water to be detected according to the scattered light intensity and/or the fluorescence intensity. According to the water quality detection method, the fluorescent dye is used for dyeing the sample water to be detected, then laser is adopted to radiate the sample water to be detected, the detection result is acquired according to the generated scattered light and/or fluorescence intensity. As the water quality of the sample water to be detected is analyzed by detecting the scattered light and/or fluorescence intensity, the detection result can be quickly acquired, the detection time is saved, and the detection efficiency is improved.

Water quality detection method and system

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