Walter Schubert
Otto-von-Guericke University Magdeburg
68 Papers
556 Citations
Walter Schubert is an academic researcher from Otto-von-Guericke University Magdeburg. The author has contributed to research in topics: Skeletal muscle & Amyloid precursor protein. The author has an hindex of 22, co-authored 68 publications. Previous affiliations of Walter Schubert include Zenit & Heidelberg University.
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Papers
Analyzing proteome topology and function by automated multidimensional fluorescence microscopy
Walter Schubert,Walter Schubert,Bernd Bonnekoh,Ansgar J. Pommer,Lars Philipsen,Raik Böckelmann,Yanina Malykh,Harald Gollnick,Manuela Friedenberger,Marcus Bode,Marcus Bode,Andreas W. M. Dress +11 more
TL;DR: By analyzing many cell and tissue types, this approach reveals rules of hierarchical protein network organization, in which the frequency distribution of different protein clusters obeys Zipf's law, and state-specific lead proteins appear to control protein network topology and function.
Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites
Walter Schubert,R. Prior,Andreas Weidemann,Heinrich Dircksen,Gerd Multhaup,Colin L. Masters,Konrad Beyreuther +6 more
TL;DR: A preferential localization of APP is reported at synaptic sites of human and rat brain and at neuromuscular junctions, implying a role of APP in physiological synaptic activity and a potential and early impairment of central synapses when synaptic APP is converted to beta A4 amyloid during the pathological evolution of Alzheimer's disease and Down's syndrome.
279
Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human skeletal muscle.
TL;DR: It is reported that monoclonal antibody Leu-19 (mAb-Leu19) labels structures in human skeletal muscle: satellite cells, which form the stem cell pool of muscle fiber regeneration, both in normal and diseased muscle; myotubes and myotube projections in regions of Muscle fiber repair; periodically organized fibrillar structures in areas of regeneration.
147
Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndromea
Konrad Beyreuther,Peter Pollwein,Gerd Multhaup,Ursula Mönning,G. König,T. Dyrks,Walter Schubert,Colin L. Masters +7 more
TL;DR: The localization of APP at synaptic sites in brain suggests that APP regulation and expression are critical determinants of a potential and early impairment of central synapses.
121
Topological proteomics, toponomics, MELK-technology.
TL;DR: The present chapter summarizes the steps that have contributed to the establishment of MELK, an ultrasensitive topological proteomics technology analysing proteins on the single cell level, which addresses higher level order in a proteome, referred to as the toponome.
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