Wael Yared
PerkinElmer
23 Papers
146 Citations
Wael Yared is an academic researcher from PerkinElmer. The author has contributed to research in topics: In vivo & Ex vivo. The author has an hindex of 10, co-authored 23 publications.
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Papers
Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT)
Sylvie Kossodo,Maureen Pickarski,Shu-An Lin,Alexa Gleason,Renee C. Gaspar,Chiara Buono,Guojie Ho,Agnieszka Blusztajn,Garry Cuneo,Jun Zhang,Jayme Jensen,Richard Hargreaves,Paul J. Coleman,George D. Hartman,Milind Rajopadhye,Le Thi Duong,Cyrille Sur,Wael Yared,Jeffrey D. Peterson,Bohumil Bednar +19 more
TL;DR: NIRF-labeled integrin antagonists allow noninvasive molecular fluorescent imaging and quantification of tumors in vivo, improving and providing more refined approaches for cancer detection and treatment monitoring.
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In Vivo Imaging and Quantification of Carbonic Anhydrase IX Expression as an Endogenous Biomarker of Tumor Hypoxia
Bagna Bao,Kevin Groves,Jun Zhang,Emma Handy,Paul Kennedy,Garry Cuneo,Claudiu T. Supuran,Wael Yared,Milind Rajopadhye,Jeffrey D. Peterson +9 more
TL;DR: A spatial correlation of fluorescence signal obtained by non-invasive, tomographic imaging of HS680 with regions of hypoxia and CA IX expression is established, crucial to the study of the underlying biology of hypoxic tumors and the development and monitoring of novel anti-cancer therapies.
Noninvasive In Vivo Quantification of Neutrophil Elastase Activity in Acute Experimental Mouse Lung Injury
Sylvie Kossodo,Jun Zhang,Kevin Groves,Garry Cuneo,Emma Handy,Jeff Morin,Jeannine Delaney,Wael Yared,Milind Rajopadhye,Jeffrey D. Peterson +9 more
TL;DR: A neutrophil elastase-specific near-infrared fluorescence imaging agent was developed, which was significantly activated ex vivo in lung sections from ALI but not from control mice, and this activation was ablated by the specific inhibitor sivelestat.
Patent
Imaging Systems Featuring Waveguiding Compensation
Wael Yared,Pouyan Mohajerani,Joshua Kempner +2 more
- 03 Jun 2008
TL;DR: In this article, the authors proposed a method for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding.
25
Patent
Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
Jorge Ripoll Lorenzo,Wael Yared,Joshua Kempner +2 more
- 27 Aug 2010
TL;DR: In this paper, a hybrid Fourier approach is presented that enables the fast tomographic reconstruction of large datasets, which preserves the three-dimensional fluorophore distribution and quantitative nature of the FMT approach while substantially accelerating its computation speed.
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