W.-q. Wei
6 Papers
1 Citations
W.-q. Wei is an academic researcher. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 1, co-authored 5 publications.
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Papers
Inference of causal relationships based on the genetics of cardiometabolic traits and conditions unique to females in >50,000 participants
Bowei Xiao,Digna R. Velez Edwards,Anastasia Lucas,Theodore G. Drivas,Kent A. Gray,Brendan J. Keating,Chen Weng,G. Jarvik,Hakon Hakonarson,Leah C. Kottyan,Noémie Elhadad,Regeneron Genetics Center,W.-q. Wei,Y Ruben Luo,D. Kim,Marylyn D. Ritchie,Shefali S. Verma +16 more
TL;DR: Polygenic susceptibility to cardiometabolic traits is associated with conditions unique to females and individuals with high PRS are also more likely to develop conditions such as PCOS and gestational hypertension at earlier ages.
Polygenic risk vectors (PRV) improve genetic risk stratification for cardio-metabolic diseases
R. Li,Xu Zhang,B.Y. Li,Qijia Feng,Leah C. Kottyan,Y Luo,Konrad T Sawicki,N. Limdi,Megan J. Puckelwartz,W.-q. Wei,Ching Ho Weng,Y. Chen,Marylyn D. Ritchie,Jocelyn Moore +13 more
TL;DR: It is found that the combined effects between the additive PRS and the dominant PRS outperformed either one in terms of disease risk stratification, especially for the individuals in the high-risk group.
Characterizing Variability of EHR-Driven Phenotype Definitions
Pascal S. Brandt,Abel N. Kho,Y Ruben Luo,Jennifer A. Pacheco,Theresa L. Walunas,Hakon Hakonarson,George Hripcsak,C. Liu,Ning Shang,Christine Weng,Norman. C. Walton,D. Carrell,P. K. Crane,E. Larson,Christopher G. Chute,I. Kullo,Robert J. Carroll,Janice C. Denny,Alex Ramirez,W.-q. Wei,John Pathak,Laura K. Wiley,Rachel L. Richesson,Justin Starren,Luke V. Rasmussen +24 more
TL;DR: The phenotypes analyzed show significant variation in specific logical, arithmetic and other operators, but are all composed of the same high-level components, namely tabular data and logical expressions.
Mixed-effects polygenic risk score Phenome-wide association study detects genetic correlation between colorectal cancer risk and phenotype data extracted from the electronic health record
E. A. Rosenthal,W.-q. Wei,Y. Luo,B. Namjou-Khales,D. Schaid,E. D. Esplin,M. Lape,L. Kottyan,J. A. P. A. Pacheco,Ching Ho Weng,A. Gordon,I.J. Kullo,D. Crosslin,W. M. Grady,L. Hsu,U. Peters,G. Jarvik +16 more
Leveraging Generative AI to Prioritize Drug Repurposing Candidates: Validating Identified Candidates for Alzheimer's Disease in Real-World Clinical Datasets
W.-q. Wei,Cheng-Kai Yan,Monika Grabowska,Alyson L Dickson,Zhi Wen,Dm Roden,Casey Stein,Peter J. Embi,J. Peterson,Q. Feng,Bradley A. Malin +10 more
TL;DR: In this paper , the authors used ChatGPT to identify drug repurposing candidates for Alzheimer's disease (AD) and tested the top ten for risk of incident AD in exposed and unexposed individuals over age 65.