Excitotoxicity and stroke: identifying novel targets for neuroprotection.

Adenosine and cerebral ischemia: therapeutic future or death of a brave concept?

http://rabbit.if-pan.krakow.pl/pjp/pdf/2009/2_225.pdf

Pharmacology of dimethyl sulfoxide in cardiac and CNS damage

Neuronal damage in the central nervous system leads to primary cell death, induced directly by the trauma, and delayed secondary death of neurons, the latter depending on environmental changes, lack of metabolic and trophic supply, and altered gene transcription. While primary death of neurons occurring within a short time after trauma is not a realistic target for therapy, secondary cell death might be prevented by new neuroprotective strategies. Although there are increasing data concerning cell rescue after ischemic and traumatic brain injury through the last decade, the mechanisms that underlie secondary death of neurons following lesion are still incompletely understood and are now the subject of a more detailed investigation. In this review, we want to give an overview on what is known about the molecular mechanisms of delayed ischemic and traumatic neuronal death in vivo and about promising neuroprotective treatment strategies that might be of future clinical relevance or have already entered clinical trials.

Neuronal death after brain injury. Models, mechanisms, and therapeutic strategies in vivo.

In developed countries, ischemic stroke is one of the leading causes of death and neurological impairment. The two most important therapeutic approaches in patients with acute cerebral ischemia consis

Current status and perspectives of neuroprotection in ischemic stroke treatment.

Efficacy and Tolerability of Lifarizine in Acute Ischemic Stroke. A Pilot Study

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Efficacy and Tolerability of Lifarizine in Acute Ischemic Stroke. A Pilot Study