W. Marston Linehan
National Institutes of Health
632 Papers
4.6K Citations
W. Marston Linehan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Renal cell carcinoma. The author has an hindex of 112, co-authored 568 publications. Previous affiliations of W. Marston Linehan include Armed Forces Institute of Pathology & Science Applications International Corporation.
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Papers
Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice
Shun Kishimoto,Jeffrey R. Brender,Daniel R. Crooks,Shingo Matsumoto,Tomohiro Seki,Nobu Oshima,Hellmut Merkle,Penghui Lin,Galen D. Reed,Albert P. Chen,Jan Henrik Ardenkjær-Larsen,Jan Henrik Ardenkjær-Larsen,Jeeva Munasinghe,Keita Saito,Kazutoshi Yamamoto,Peter L. Choyke,James E. Mitchell,Andrew N. Lane,Teresa W.-M. Fan,W. Marston Linehan,Murali Krishna +20 more
TL;DR: It is demonstrated that tumor xenografts with a similar genetic background can be distinguished by their differing rates of the metabolism of 13C labeled glucose tracers, which can be imaged without hyperpolarization by using newly developed techniques for noise suppression.
von Recklinghausen's disease and pheochromocytomas.
TL;DR: Pheochromocytomas occur in a small but defined number of patients with von Recklinghausen's disease, and can be associated with significant morbidity and mortality if not detected.
Targeting loss of the Hippo signaling pathway in NF2-deficient papillary kidney cancers.
Carole Sourbier,Pei-Jyun Liao,Christopher J. Ricketts,Darmood Wei,Youfeng Yang,Sarah M. Baranes,Benjamin K. Gibbs,Lernik Ohanjanian,L. Spencer Krane,Bradley T. Scroggins,J. Keith Killian,Ming-Hui Wei,Toshiki Kijima,Paul S. Meltzer,Deborah Citrin,Len Neckers,Cathy D. Vocke,W. Marston Linehan +17 more
TL;DR: In this paper, the authors investigated the importance of YAP and Yes activity in three NF2-deficient renal cell carcinomas (PRCC) cell lines and showed that inhibiting Yes and the subsequent transcriptional activity had a substantial anti-tumor cell effect both in vitro and in vivo and may provide a viable therapeutic approach for patients with NF2deficient PRCC.
Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC).
TL;DR: The combination of gender and mutation of a specific gene, such as BAP1, may have implications not only for prognosis but also for understanding the role of chromatin remodeling gene mutations in kidney cancer progression.
Long term organ culture of human prostate tissue in a nasa-designed rotating wall bioreactor
Leonid Margolis,Steven Hatfill,Rodrigo F. Chuaqui,Cathy D. Vocke,Michael R. Emmert-Buck,W. Marston Linehan,Paul H. Duray +6 more
TL;DR: The RWV bioreactor represents an additional new technology for culturing prostate tissue for further investigations concerning the basic physiology and pathobiology of this clinically important tissue.