W. Mark Brown
Wake Forest University
47 Papers
625 Citations
W. Mark Brown is an academic researcher from Wake Forest University. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 25, co-authored 42 publications. Previous affiliations of W. Mark Brown include University of Miami & Quinnipiac University.
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Papers
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage
Daniel Woo,Guido J. Falcone,Guido J. Falcone,William J. Devan,William J. Devan,W. Mark Brown,Alessandro Biffi,Alessandro Biffi,Timothy D. Howard,Christopher D. Anderson,Christopher D. Anderson,H. Bart Brouwers,H. Bart Brouwers,Valerie Valant,Valerie Valant,Thomas W.K. Battey,Thomas W.K. Battey,Farid Radmanesh,Farid Radmanesh,Miriam R. Raffeld,Miriam R. Raffeld,Sylvia Baedorf-Kassis,Sylvia Baedorf-Kassis,Ranjan Deka,Jessica G. Woo,Lisa J. Martin,Mary Haverbusch,Charles J Moomaw,Guangyun Sun,Joseph P. Broderick,Matthew L. Flaherty,Sharyl Martini,Dawn Kleindorfer,Brett M. Kissela,Mary E. Comeau,Jeremiasz M. Jagiella,Helena Schmidt,Paul Freudenberger,Alexander Pichler,Christian Enzinger,Björn M. Hansen,Bo Norrving,Jordi Jimenez-Conde,Jordi Jimenez-Conde,Eva Giralt-Steinhauer,Eva Giralt-Steinhauer,Roberto Elosua,Roberto Elosua,Elisa Cuadrado-Godia,Elisa Cuadrado-Godia,Carolina Soriano,Carolina Soriano,Jaume Roquer,Jaume Roquer,Peter Kraft,Alison M. Ayres,Kristin Schwab,Jacob L. McCauley,Joanna Pera,Andrzej Urbanik,Natalia S. Rost,Natalia S. Rost,Joshua N. Goldstein,Anand Viswanathan,Eva Maria Stögerer,David L. Tirschwell,Magdy Selim,Devin L. Brown,Scott Silliman,Bradford B. Worrall,James F. Meschia,Chelsea S. Kidwell,Joan Montaner,Israel Fernandez-Cadenas,Pilar Delgado,Rainer Malik,Martin Dichgans,Steven M. Greenberg,Peter M. Rothwell,Arne Lindgren,Agnieszka Slowik,Reinhold Schmidt,Carl D. Langefeld,Jonathan Rosand,Jonathan Rosand +84 more
TL;DR: A genome-wide association study of this condition that meta-analyzed data from six studies that enrolled individuals of European ancestry demonstrated biological heterogeneity across ICH subtypes and highlighted the importance of ascertaining ICH cases accordingly.
Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21
TL;DR: Significant associations with ischemic stroke were observed for SNPs from the same haplotype block previously associated with myocardial infarction and this association shares pathogenic mechanisms with heart disease and diabetes, suggesting a genetic association for stroke.
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APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors.
Barry I. Freedman,Stephen O. Pastan,Ajay K. Israni,David P. Schladt,Bruce A. Julian,Michael D. Gautreaux,Vera Hauptfeld,Robert A. Bray,Howard Gebel,Allan D. Kirk,Robert S. Gaston,Jeffrey Rogers,Alan C. Farney,Giuseppe Orlando,Robert J. Stratta,Sumit Mohan,Lijun Ma,Carl D. Langefeld,Donald W. Bowden,Pamela J. Hicks,Nicholette D. Palmer,Amudha Palanisamy,Amber Reeves-Daniel,W. Mark Brown,Jasmin Divers +24 more
TL;DR: Shorter renal allograft survival is reproducibly observed after deceased-donor kidney transplantation from APOL1 2-renal-risk-variant donors, and younger recipient age and older donor age have independent adverse effects on renal allogsraft survival.
Genetic linkage and association of Fcγ receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus
Jeffrey C. Edberg,Carl D. Langefeld,Jianming Wu,Kathy L. Moser,Kenneth M. Kaufman,Jennifer A. Kelly,Vipin Bansal,W. Mark Brown,Jane E. Salmon,Stephen S. Rich,John B. Harley,Robert P. Kimberly +11 more
TL;DR: These data are the first to demonstrate linkage and both family-based and case-control-based association of FcgammaRIIIA with SLE and provide genetic evidence supporting a role for the physiologically relevant single nucleotide polymorphism of the FcGammaR IIIA gene in the pathophysiology of this complex genetic disease.
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