W. Lee
5 Papers
6 Citations
W. Lee is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 5 publications.
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Papers
Evidence for SARS-CoV-2 Delta and Omicron co-infections and recombination
Alexandre Bolze,S. White,Tina Basler,Andrew Dei Rossi,Pavitra Roychoudhury,Alexander L. Greninger,Kathleen C. Hayashibara,D. R. Wyman,E. Kil,H. Dai,T. Cassens,K H Tsan,J. Nguyen,J. Ramirez,S. Carter,Elizabeth T. Cirulli,Kelly M. Schiabor Barrett,Pedro Belda-Ferre,Nicole L. Washington,S. Jacobs,Efren Sandoval,Dirk Becker,J. T. Lu,Magnus Isaksson,W. Lee,Shengmei Luo +25 more
TL;DR: In this article , the presence and fraction of reads supporting mutations specific to either the Delta or Omicron variants of SARS-CoV-2 was analyzed and the authors identified 18 co-infections, one of which displayed evidence of a low Delta-Omicron recombinant virus population.
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A method for variant agnostic detection of SARS-CoV-2, rapid monitoring of circulating variants, detection of mutations of biological significance, and early detection of emergent variants such as Omicron
E. Lai,Dirk Becker,Pius Brzoska,T. Cassens,Jeremy Davis-Turak,E. Diamond,Manohar R. Furtado,M. Gandhi,Dennis Gort,Alexander L. Greninger,Pega Hajian,Kathleen C. Hayashibara,Elaine Kennedy,Marc Laurent,W. Lee,N. Leonetti,Jean Lozach,J. T. Lu,J. Nguyen,Karen O'donovan,T. Peck,Gail Radcliffe,J. Ramirez,Pavitra Roychoudhury,Efren Sandoval,Bruce Walsh,M. Weinell,Christopher Wesselman,Timothy Wesselman,S. White,Shanado Williams,Digna Wong,R S Creager +32 more
TL;DR: A Polymerase Chain Reaction (PCR)-based genotyping approach that is significantly less expensive, accelerates reporting on SARS-CoV-2 variants, and can be implemented in any testing lab performing PCR is described.
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TTN truncating variants in hiPSI exons show high penetrance for cardiomyopathy in carriers with atrial fibrillation
Kelly M. Schiabor Barrett,Elizabeth T. Cirulli,Alexandre Bolze,Chris J. Rowan,Gai Elhanan,Joe J Grzymski,W. Lee,Nicole L. Washington +7 more
TL;DR: This work provides statistical support for a hiPSI variant interpretation model for TTNtvs and evidence for the first population-level screening method with clinical utility for cardiomyopathies, especially in relation to an Afib finding.
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A power-based sliding window approach to evaluate the clinical impact of rare genetic variants
Elizabeth T. Cirulli,Kelly M. Schiabor Barrett,Alexandre Bolze,Joe J Grzymski,W. Lee,Nicole L. Washington +5 more
TL;DR: PW showcases that EHR-based statistical analyses can accurately distinguish between novel coding variants that will have high phenotypic penetrance in a population and those that will not, unlocking new potential for population genetic screening.
2
Not To Skip Yet: Impact of Intravenous Thrombolysis on Final Infarction Volume and Clinical Outcomes in early Arrivals Acute Large Vessel Occlusion: A Retrospective Cohort Study.
Ghada A. Mohamed,Muhammed Amir Essibayi,Valerie Sharf,Hasenah Ali,W. Lee,Robert Fugatt,Karen S. Jacks,H.M. Abou-nour,Maria Vittoria Spampinato,Ashley Wabnitz,Christine A Holmstedt +10 more
TL;DR: In this article , the authors evaluated the effect of IVT in reducing the final infarction volume (FIV) after complete recanalization for acute large vessel occlusion (LVO) stroke patients.